Product image of Molaxole (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Molaxole

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Molaxole (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Molaxole, is an osmotic laxative presented as an oral powder for oral use. It facilitates bowel cleansing in adults undergoing diagnostic or surgical procedures and can relieve occasional constipation.
GNH India supplies Molaxole as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Molaxole is used as an osmotic agent to manage bowel preparation and constipation.

  • Constipation: softens stool by retaining water in the intestinal lumen, promoting regular bowel movements.
  • Colonoscopy preparation: induces osmotic diarrhea to clear the colon, improving endoscopic visualization.
  • Pre‑operative bowel cleansing: reduces fecal load before abdominal surgery, helping to lower infection risk.

How It Works

  • Macrogol 3350 creates an osmotic gradient that draws water into the intestinal lumen, increasing stool volume and softness. Sodium hydrogen carbonate and sodium chloride provide an electrolyte balance that maintains plasma osmolality, while potassium chloride supplies potassium to prevent electrolyte depletion. The combined effect promotes gentle, non‑stimulating bowel evacuation without significant intestinal irritation.

Side Effects

Molaxole may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating: sensation of fullness or swelling in the abdomen.
  • Nausea: mild to moderate feeling of sickness.
  • Flatulence: increased intestinal gas.
  • Diarrhea: loose stools occurring after dose.
  • Abdominal cramps: intermittent cramping pain.
  • Thirst: increased desire for fluids.

Serious or Rare Side Effects

  • Electrolyte imbalance: abnormal sodium or potassium levels.
  • Severe dehydration: excessive fluid loss leading to low blood pressure.
  • Allergic reaction: rash, itching, or swelling of the face.
  • Renal impairment: worsening kidney function in susceptible individuals.
  • Severe abdominal pain: persistent, intense pain requiring medical attention.
  • Hypersensitivity anaphylaxis: rare, life‑threatening allergic response.

Precautions & Warnings

Before using Molaxole, consider the following safety measures.

  • Assess renal function: ensure adequate kidney function to handle fluid shifts.
  • Monitor electrolyte status: check sodium and potassium levels, especially in patients on diuretics.
  • Avoid in intestinal obstruction: contraindicated where bowel passage is blocked.
  • Use with caution in the elderly: higher risk of dehydration and electrolyte disturbances.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Molaxole can interact with other medications that affect fluid or electrolyte balance.

Major Interactions (Avoid)

  • Concurrent osmotic laxatives: risk of severe fluid loss.
  • High‑dose potassium supplements: may cause hyperkalemia.
  • Diuretics: can exacerbate electrolyte disturbances.

Moderate Interactions (Monitor Closely)

  • Antacids containing sodium bicarbonate: increase sodium load.
  • ACE inhibitors: monitor potassium levels.
  • NSAIDs: watch for renal function changes.

Frequently Asked Questions

Molaxole is an oral powder that contains macrogol 3350 and electrolytes. It is primarily used to cleanse the bowel before procedures such as colonoscopy or abdominal surgery, and it can also provide relief for occasional constipation by softening stool and promoting natural evacuation.

Macrogol 3350 is an osmotic polymer that retains water within the intestinal lumen. This increased water content softens the stool and expands its volume, leading to gentle, non‑stimulating bowel movements. The accompanying electrolytes help maintain fluid balance during the cleansing process.

The dose of Molaxole is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical indication and renal function. Only a qualified prescriber should set the appropriate amount and administration schedule.

Safety data for Molaxole in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Molaxole, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Molaxole combines macrogol 3350 with balanced electrolytes, offering effective bowel cleansing with a lower risk of significant electrolyte disturbance compared with some sodium‑based preparations. It is generally well tolerated, but the choice of agent should be based on patient factors, procedural requirements and clinician preference.

Molaxole should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture. Keep the container tightly closed and out of direct sunlight to maintain product stability.

Molaxole is taken orally, usually dissolved in a specified volume of water as instructed by the prescriber. The solution is consumed according to the dosing schedule provided, often in divided doses to achieve the desired bowel preparation.

The most serious risks include severe electrolyte imbalance, marked dehydration, and rare allergic reactions such as anaphylaxis. Patients with compromised kidney function or those taking interacting medications should be monitored closely for these complications.

Molaxole should be avoided in individuals with known intestinal obstruction, severe renal impairment, or hypersensitivity to any of its components. It is also contraindicated in patients who are unable to maintain adequate fluid intake during the cleansing process.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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