Molaxole (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Molaxole is an osmotic laxative that acts on the gastrointestinal tract to alleviate constipation.

• Functional constipation: softens stool and promotes regular bowel movements.
• Opioid‑induced constipation: counteracts opioid‑related reduced intestinal motility.
• Chronic idiopathic constipation: provides sustained stool hydration for long‑term management.

• Molaxole contains macrogol 3350 together with electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride). The macrogol polymer creates an osmotic gradient that draws water into the intestinal lumen, increasing stool water content. The added electrolytes maintain fluid balance and prevent excessive electrolyte loss, allowing the softened stool to be passed more easily through peristalsis. This mechanism results in a gentle, non‑stimulant laxation effect.

Molaxole may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Abdominal bloating: feeling of fullness in the abdomen.
• Flatulence: increased gas production.
• Nausea: mild queasiness.
• Mild abdominal cramps: intermittent stomach discomfort.
• Diarrhea: loose stools.
• Thirst: increased desire to drink fluids.

Serious or Rare Side Effects

• Severe electrolyte imbalance: abnormal sodium or potassium levels.
• Severe dehydration: marked loss of body fluids.
• Allergic reaction: rash, itching, swelling, or angioedema.
• Severe abdominal pain: intense, persistent pain.
• Rectal bleeding: blood in stool.
• Intestinal obstruction signs: vomiting, inability to pass gas.

When using Molaxole, certain precautions should be observed to ensure safe and effective therapy.

• Assess renal function: evaluate kidney health before initiating therapy.
• Monitor electrolyte balance: check serum sodium and potassium during treatment.
• Use with caution in dehydration: ensure adequate fluid intake.
• Avoid in known bowel obstruction: contraindicated if mechanical blockage is present.
• Adjust dose in elderly patients: start with the lowest effective amount.
• Store at ambient temperature: keep in original packaging, protect from moisture.

Molaxole can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

• Concurrent osmotic laxatives: may cause excessive fluid loss.
• Loop diuretics: increase risk of electrolyte disturbances.
• Potassium‑containing supplements: risk of hyperkalemia.
• NSAIDs: may exacerbate renal impairment when combined.

Moderate Interactions (Monitor Closely)

• Anticholinergic agents: may reduce laxative effectiveness.
• Opioid analgesics: may require higher laxative dose.
• Antacids: possible alteration of electrolyte composition.