Product image of Molaxole (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Molaxole

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Molaxole (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Sodium Hydrogen Carbonate, the active ingredient in Molaxole, is an osmotic laxative presented as an oral powder for oral use. It is combined with potassium chloride, sodium chloride and macrogol 3350 to facilitate bowel cleansing and relieve constipation in adult patients.

GNH India supplies Molaxole as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Molaxole is used as an osmotic laxative for bowel preparation and constipation management.

  • Colonoscopy preparation: clears the colon to improve visualization during the procedure.
  • Chronic constipation: softens stool and promotes regular bowel movements.
  • Electrolyte balance support: provides potassium and sodium ions to replace losses during bowel cleansing.

How It Works

  • Molaxole works by creating an osmotic gradient in the intestinal lumen. The macrogol 3350 polymer retains water, while the electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) maintain isotonicity. This combination draws water into the bowel, softening stool and increasing intestinal volume, which stimulates peristalsis and facilitates evacuation.

Side Effects

Molaxole may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate feeling of sickness.
  • Abdominal bloating: sensation of fullness or swelling.
  • Flatulence: increased intestinal gas.
  • Diarrhea: loose, watery stools.
  • Electrolyte imbalance: mild changes in sodium or potassium levels.
  • Headache: occasional mild headache.

Serious or Rare Side Effects

  • Severe dehydration: marked loss of body fluids.
  • Significant electrolyte disturbances: hypernatremia or hypokalemia.
  • Allergic reaction: rash, itching, or swelling.
  • Acute renal impairment: sudden decrease in kidney function.
  • Severe abdominal pain: persistent or worsening pain.
  • Syncope: fainting episodes.

Precautions & Warnings

Before using Molaxole, consider the following safety measures.

  • Assess renal function: avoid in severe renal impairment.
  • Monitor electrolytes: check serum sodium and potassium levels in at-risk patients.
  • Evaluate gastrointestinal obstruction: contraindicated if obstruction is suspected.
  • Use with caution in the elderly: increased risk of dehydration.
  • Review concomitant laxatives: avoid simultaneous use of other osmotic agents.
  • Store at ambient temperature: keep below 25°C, in the original packaging, protected from moisture.

Avoid Interactions

Molaxole can interact with other medicines that affect fluid or electrolyte balance.

Major Interactions (Avoid)

  • Loop diuretics: may exacerbate electrolyte loss.
  • ACE inhibitors or ARBs: increased risk of hyperkalemia.
  • Sodium‑containing medications: can cause excessive sodium load.

Moderate Interactions (Monitor Closely)

  • Antacids containing magnesium or aluminum: may alter absorption.
  • Other laxatives or stool softeners: additive effect on bowel motility.
  • Antihypertensives: monitor blood pressure due to potential volume shifts.

Frequently Asked Questions

Molaxole is an oral osmotic laxative indicated for bowel cleansing before diagnostic procedures such as colonoscopy and for the symptomatic relief of occasional constipation in adults.

Macrogol 3350 creates an osmotic gradient that retains water in the intestinal lumen, while the accompanying electrolytes maintain isotonicity. This increases stool water content, softens the stool, and stimulates peristalsis to promote evacuation.

The dose of Molaxole is individualized by the prescribing healthcare professional based on the indication, patient age, weight, and renal function. Patients should follow the prescriber’s specific instructions.

Safety of Molaxole in pregnancy or lactation has not been fully established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and after consultation with a qualified healthcare provider.

To order Molaxole, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Molaxole combines macrogol 3350 with electrolytes, offering an isotonic solution that is generally well tolerated and less likely to cause severe electrolyte shifts compared with some high‑volume saline‑based preparations. Choice of agent depends on patient factors, procedural requirements and physician preference.

Molaxole should be stored at ambient temperature, below 25 °C, in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposure to extreme temperatures.

Molaxole is taken orally as a powder that is dissolved in water according to the prescriber’s instructions. The solution is usually consumed in divided doses over a specified period, often the evening before and the morning of the procedure.

Serious risks include severe dehydration, significant electrolyte disturbances (such as hypernatremia or hypokalemia), acute renal impairment, and rare allergic reactions. Patients should seek medical attention if they experience persistent vomiting, dizziness, fainting, or severe abdominal pain.

Molaxole is contraindicated in patients with known hypersensitivity to any component, intestinal obstruction, severe renal impairment, or uncontrolled electrolyte imbalances. It should also be used with caution in the elderly and in patients taking medications that affect fluid or electrolyte status.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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