Product image of Molgeom Uno (Molsidomine) supplied by GNH India

Molgeom Uno

Active Ingredient:
Molsidomine
Origin:
EU

Molgeom Uno (Molsidomine)

Molsidomine, the active ingredient in Molgeom Uno, is a nitric oxide donor presented as an oral dosage form for oral use. It is employed to manage stable angina pectoris in adult patients, helping to alleviate chest pain by improving coronary blood flow. The drug is metabolized to l‑citrulline, which releases nitric oxide, producing vasodilation and reducing cardiac preload and afterload.

GNH India supplies Molgeom Uno as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable global distribution.

Manufacturer / TM Owner

Therabel Pharma S.A.

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Indications & Clinical Uses

Molsidomine acts as a nitric oxide donor to relieve myocardial ischemia in angina‑related conditions.

  • Stable angina pectoris: reduces frequency and severity of chest pain episodes
  • Chronic stable angina: improves exercise tolerance and delays onset of angina during physical activity
  • Ischemic heart disease: decreases myocardial oxygen demand by lowering cardiac preload and afterload

How It Works

  • After oral administration, molsidomine is rapidly absorbed and converted by hepatic enzymes to its active metabolite, l‑citrulline. l‑Citrulline is further transformed into nitric oxide, which activates soluble guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of smooth muscle, vasodilation, and a reduction in both preload and afterload, thereby improving myocardial oxygen balance.

Side Effects

Molsidomine may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Headache
  • Flushing
  • Dizziness
  • Nausea
  • Hypotension

Serious or Rare Side Effects

  • Severe hypotension
  • Syncope
  • Allergic reactions (rash, urticaria, anaphylaxis)
  • Worsening angina or myocardial infarction (rare)

Precautions & Warnings

When prescribing molsidomine, clinicians should observe several precautionary measures to ensure patient safety.

  • Monitor blood pressure: check baseline and periodic measurements to detect hypotension
  • Avoid use in severe hypotension: contraindicated in patients with markedly low blood pressure
  • Caution in heart failure: assess cardiac function before initiation
  • Assess hepatic function: dose adjustment may be required in severe liver impairment
  • Do not discontinue abruptly: tapering may be needed to avoid rebound angina
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight

Avoid Interactions

Molsidomine can interact with other agents that affect vascular tone or blood pressure.

Major Interactions (Avoid)

  • Nitrate donors (e.g., nitroglycerin, isosorbide dinitrate): additive vasodilation may cause severe hypotension
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil, vardenafil): risk of profound hypotension
  • Sodium nitroprusside: combined effect may lead to excessive blood pressure drop

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs (ACE inhibitors, ARBs, calcium channel blockers): may enhance blood pressure‑lowering effect
  • Beta‑blockers: may mask tachycardic response to hypotension
  • Alcohol: can potentiate hypotensive effects, requiring caution

Frequently Asked Questions

Molgeom Uno contains molsidomine, which is prescribed to treat stable angina pectoris. By improving coronary blood flow, it helps reduce the frequency and intensity of chest pain episodes in patients with chronic stable angina.

Molsidomine is converted in the body to l‑citrulline, which then releases nitric oxide. The nitric oxide activates soluble guanylate cyclase, raising cyclic GMP levels and causing smooth‑muscle relaxation, vasodilation, and a reduction in cardiac preload and afterload.

The appropriate dose of molsidomine is determined by the prescribing clinician based on the individual patient's condition, response, and any concomitant therapies. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for molsidomine during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Molgeom Uno product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Molsidomine belongs to the nitric oxide donor class, offering vasodilation without the rapid tolerance seen with some nitrates. Compared with beta‑blockers or calcium‑channel blockers, it primarily reduces preload and afterload, making it a useful alternative or adjunct in patients who cannot tolerate other agents.

Molgeom Uno should be stored at room temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight and sources of heat to maintain its stability and potency.

Molgeom Uno is taken orally, usually as a tablet, with or without food as directed by the prescriber. Patients should swallow the tablet whole and avoid crushing or chewing unless specifically instructed.

The most serious risks include severe hypotension, syncope, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience sudden dizziness, fainting, or signs of a severe allergic response.

Molgeom Uno is contraindicated in patients with known severe hypotension, those who have experienced allergic reactions to molsidomine or related nitric oxide donors, and individuals using other nitrate or phosphodiesterase‑5 inhibitor therapies without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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