Product image of Molipaxin (Trazodone Hydrochloride) supplied by GNH India

Molipaxin

Active Ingredient:
Trazodone Hydrochloride
Origin:
EU

Molipaxin (Trazodone Hydrochloride)

Trazodone Hydrochloride, the active ingredient in Molipaxin, is a serotonin antagonist and reuptake inhibitor (SARI) presented as an oral dosage form for oral use. It is prescribed for the treatment of major depressive disorder in adult patients.

GNH India supplies Molipaxin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and other healthcare providers worldwide, with a focus on quality and regulatory compliance.

Manufacturer / TM Owner

Zentiva Pharma Uk Limited

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Molipaxin (trazodone hydrochloride) is used in the management of depressive disorders by modulating serotonergic pathways.

  • Major depressive disorder: reduces depressive symptoms and improves mood in adult patients.
  • Depressive disorder with insomnia: assists in improving sleep while treating depressive symptoms.
  • Anxiety associated with depression: may lessen anxiety symptoms in patients who have co‑existing depressive illness.

How It Works

  • Trazodone hydrochloride acts as an antagonist at 5‑HT2A receptors while simultaneously inhibiting the reuptake of serotonin. This dual action increases serotonergic neurotransmission in the central nervous system, leading to enhanced mood regulation and anxiolytic effects that are characteristic of serotonin antagonist and reuptake inhibitor (SARI) agents.

Side Effects

Trazodone may cause a range of adverse reactions, some of which are more frequent than others.

Common Side Effects

  • Dizziness
  • Drowsiness or somnolence
  • Dry mouth
  • Headache
  • Nausea
  • Blurred vision

Serious or Rare Side Effects

  • Priapism (prolonged erection)
  • Serotonin syndrome when combined with other serotonergic drugs
  • Cardiac arrhythmias or QT prolongation
  • Severe hypotension
  • Hepatic injury
  • Emergence of suicidal thoughts or behaviors

Precautions & Warnings

When prescribing Molipaxin, clinicians should consider several safety measures.

  • Psychiatric assessment: evaluate for suicidal ideation before and during therapy.
  • Hepatic function: use caution in patients with liver impairment and monitor liver enzymes.
  • Elderly patients: start at lower doses and titrate slowly due to increased sensitivity.
  • Discontinuation: avoid abrupt cessation to reduce risk of withdrawal symptoms.
  • Concomitant CNS depressants: monitor for additive sedation.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Trazodone can interact with a variety of medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of severe serotonin syndrome.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol, linezolid): may precipitate serotonin toxicity.
  • Alcohol: enhances sedative effects and can increase dizziness.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise trazodone plasma levels.
  • Antihypertensive drugs: additive hypotensive effect.
  • Central nervous system depressants (e.g., benzodiazepines, antihistamines): monitor for excessive sedation.

Frequently Asked Questions

Molipaxin contains trazodone hydrochloride and is indicated for the treatment of major depressive disorder in adult patients. It helps alleviate depressive symptoms by enhancing serotonergic activity in the brain.

Trazodone hydrochloride blocks 5‑HT2A receptors while inhibiting serotonin reuptake. This dual mechanism increases the amount of serotonin available at synapses, improving mood regulation and producing antidepressant and anxiolytic effects.

The appropriate dose of Molipaxin is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and tolerability. Dosage regimens are not standardized and should follow the prescriber’s instructions.

Safety data for trazodone use in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Molipaxin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Molipaxin (trazodone) belongs to the SARI class, differing from selective serotonin reuptake inhibitors (SSRIs) by also antagonising 5‑HT2A receptors. This profile can result in less sexual dysfunction but may cause more sedation and orthostatic hypotension compared with many SSRIs.

Molipaxin should be stored at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Molipaxin is taken orally, usually with food or a light snack to reduce gastrointestinal irritation. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or split unless specifically instructed by a healthcare professional.

Serious risks include priapism, serotonin syndrome (especially when combined with other serotonergic agents), severe hypotension, cardiac arrhythmias, hepatic injury, and the emergence or worsening of suicidal thoughts. Patients should seek immediate medical attention if any of these occur.

Molipaxin is contraindicated in patients who have taken a monoamine oxidase inhibitor within the past 14 days, those with known hypersensitivity to trazodone, and individuals with a history of priapism. Caution is also advised for patients with severe hepatic impairment or uncontrolled cardiac conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.