Product image of Molsidomin Retard Heumann (Molsidomine) supplied by GNH India

Molsidomin Retard Heumann

Active Ingredient:
Molsidomine
Origin:
EU

Molsidomin Retard Heumann (Molsidomine)

Molsidomine, the active ingredient in Molsidomin Retard Heumann, is a nitric oxide donor presented as a strength/form for oral use. It treats chronic stable angina in adults.

GNH India supplies Molsidomin Retard Heumann as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Heumann Pharma Gmbh & Co. Generica Kg

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Indications & Clinical Uses

  • Molsidomine is used in the management of angina and related cardiovascular conditions.
  • Chronic stable angina: reduces the frequency of angina attacks and improves exercise tolerance.
  • Ischemic heart disease: provides symptomatic relief of chest pain caused by myocardial ischemia.
  • Coronary artery disease: helps alleviate discomfort during exertion.

How It Works

  • Molsidomine is a prodrug that is metabolized to l‑arginine‑NO synthase‑independent nitric oxide. The released nitric oxide activates soluble guanylate cyclase, increasing cyclic GMP in vascular smooth muscle, leading to relaxation of arterial and coronary vessels and improved myocardial blood flow.

Side Effects

Molsidomine may cause several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Headache
  • Dizziness
  • Flushing
  • Nausea
  • Mild hypotension
  • Tachycardia

Serious or Rare Side Effects

  • Severe hypotension
  • Syncope
  • Allergic reactions (rash, urticaria)
  • Angioedema
  • Rare myocardial infarction
  • Elevated liver enzymes

Precautions & Warnings

  • When prescribing Molsidomine, consider the following safety measures.
  • Cardiovascular status: monitor blood pressure and heart rate regularly.
  • Concomitant nitrates: avoid additive hypotensive effects.
  • Renal impairment: use with caution and adjust if necessary.
  • Hepatic impairment: monitor liver function tests.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Molsidomine can interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Other nitric oxide donors (e.g., nitroglycerin): risk of severe hypotension.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): additive vasodilatory effect.
  • Antihypertensives (e.g., ACE inhibitors): may cause excessive blood pressure drop.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia.
  • Diuretics: enhance hypotensive effect.
  • Alcohol: may increase dizziness and hypotension.

Frequently Asked Questions

Molsidomin Retard Heumann contains molsidomine, which is prescribed to relieve symptoms of chronic stable angina by improving blood flow to the heart muscle.

Molsidomine is a prodrug that releases nitric oxide after metabolism. The nitric oxide relaxes vascular smooth muscle through the cyclic GMP pathway, causing coronary vasodilation and reducing myocardial oxygen demand.

The appropriate dose of molsidomine is determined by the prescribing physician based on the patient’s clinical condition, response, and any co‑existing medical issues.

Safety data for molsidomine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under medical supervision.

Submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Molsidomine belongs to the nitric oxide donor class, offering vasodilation without the rapid tolerance seen with nitrates. Compared with beta‑blockers or calcium‑channel blockers, it primarily improves coronary blood flow rather than reducing heart rate or contractility.

Store the product at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight and excessive heat to maintain stability.

The medication is taken orally, usually with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water.

Serious risks include severe hypotension, syncope, allergic reactions such as angioedema, and rare cases of myocardial infarction. Patients should seek immediate medical attention if they experience sudden dizziness, fainting, or signs of an allergic reaction.

Molsidomine should be avoided in patients with known hypersensitivity to the drug, those taking other nitric oxide donors, and individuals with severe hypotension or uncontrolled heart failure unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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