Momenex (Mometasone Furoate)

Mometasone furoate nasal spray acts on inflammatory processes of the nasal mucosa to relieve symptoms of allergic and obstructive conditions.

• Allergic rhinitis: reduces nasal congestion, itching, and sneezing caused by seasonal or perennial allergens.
• Nasal polyps: decreases polyp size and improves nasal airflow.
• Seasonal allergic rhinitis: alleviates acute allergy symptoms during high pollen periods.

• Mometasone furoate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses pro‑inflammatory cytokine production, inhibits activation of inflammatory cells such as eosinophils and mast cells, and reduces vascular permeability, leading to decreased nasal mucosal inflammation.

Mometasone furoate nasal spray may cause local and systemic adverse reactions.

Common Side Effects

• Nasal irritation or burning sensation
• Headache
• Epistaxis (nosebleed)
• Throat irritation or dryness
• Cough
• Altered taste or bitter taste

Serious or Rare Side Effects

• Nasal septal perforation
• Severe allergic reaction (anaphylaxis)
• Vision changes or cataract formation
• Adrenal suppression with prolonged high‑dose use
• Fungal infection of the nasal passages
• Increased intra‑ocular pressure or glaucoma exacerbation

Before using Momenex, consider the following safety measures.

• Prescription use only: follow the prescriber's instructions.
• Recent nasal surgery or trauma: avoid use until healed.
• Monitor for signs of infection: discontinue if persistent sinus infection occurs.
• Caution in patients with glaucoma or cataracts: assess intra‑ocular pressure regularly.
• Known hypersensitivity: do not use if allergic to mometasone or any formulation component.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Mometasone furoate nasal spray can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

• Systemic corticosteroids: combined use may increase risk of adrenal suppression.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise local drug exposure.
• Immunosuppressants (e.g., cyclosporine): heightened risk of local infection.

Moderate Interactions (Monitor Closely)

• Antihistamines: may reduce perceived benefit of the nasal spray.
• Intranasal decongestants: concurrent use can increase nasal irritation.