Momenex (Mometasone Furoate)

Mometasone furoate nasal spray is used to manage inflammatory nasal conditions within the allergic rhinitis disease family.

• Allergic rhinitis: alleviates nasal congestion, sneezing, itching, rhinorrhea and improves airflow by decreasing mucosal inflammation.
• Seasonal allergic rhinitis: provides symptom relief during pollen seasons through local anti‑inflammatory action.
• Perennial allergic rhinitis: controls year‑round nasal symptoms caused by indoor allergens by suppressing inflammatory mediators.

• Mometasone furoate binds to intracellular glucocorticoid receptors in nasal epithelial cells, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses the production of pro‑inflammatory cytokines, chemokines, and adhesion molecules, leading to reduced vascular permeability, edema, and infiltration of inflammatory cells in the nasal mucosa. It also stabilizes mast cells and limits the release of histamine, further contributing to symptom control.

Mometasone furoate nasal spray may cause local and systemic adverse reactions, which are categorized by frequency.

Common Side Effects

• Nasal irritation: mild burning or stinging sensation in the nasal passages.
• Headache: occasional mild to moderate headache.
• Epistaxis: occasional nosebleeds.
• Sore throat: mild irritation or discomfort.
• Altered taste: transient metallic or bitter taste.
• Cough: occasional dry cough.

Serious or Rare Side Effects

• Nasal septal perforation: rare but serious tissue damage.
• Severe allergic reaction (anaphylaxis): signs include swelling, rash, difficulty breathing.
• Adrenal suppression: potential systemic effect with prolonged high‑dose use.
• Vision changes: blurred vision or increased intra‑ocular pressure.
• Fungal infection of nasal passages: rare opportunistic infection.
• Increased intra‑ocular pressure: may affect glaucoma patients.

When using Momenex, several precautions should be observed to ensure safety and effectiveness.

• Use in children: follow pediatric dosing guidance provided by the prescriber.
• Recent nasal surgery or trauma: avoid use until healed to prevent irritation.
• Dose limitation: do not exceed the prescribed number of sprays per day.
• Concomitant nasal medications: consult a healthcare professional before combining with other nasal sprays.
• Pregnancy and lactation: discuss potential risks with a physician before initiating therapy.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Momenex may interact with other medicines; awareness of the type of interaction helps manage risk.

Major Interactions (Avoid)

• Systemic corticosteroids: concurrent use may increase risk of systemic glucocorticoid effects.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise local drug exposure.

Moderate Interactions (Monitor Closely)

• Antifungal azoles and HIV protease inhibitors: may modestly increase systemic absorption.
• Other nasal decongestants or antihistamine sprays: could enhance local irritation.
• Live vaccines: nasal corticosteroids might reduce immune response.