Mometasona Aristo (Mometasone Furoate Monohydrate)

Mometasone furoate monohydrate is a topical corticosteroid that acts on the nasal mucosa to control inflammatory responses.

• Allergic rhinitis: relief of nasal congestion, itching, sneezing and rhinorrhea.
• Seasonal allergic rhinitis: reduction of symptoms triggered by pollen or seasonal allergens.
• Nasal polyps: decrease in polyp size and improvement of nasal airflow.
• Non‑allergic rhinitis: mitigation of chronic nasal inflammation and discharge.
• Post‑operative nasal care: helps limit swelling after nasal surgery.

• Mometasone furoate monohydrate binds to intracellular glucocorticoid receptors in nasal epithelial cells, forming a receptor complex that translocates to the nucleus. This complex modulates gene transcription, suppressing pro‑inflammatory cytokines, chemokines, and adhesion molecules while enhancing anti‑inflammatory proteins. The net effect is reduced vascular permeability, edema, and immune cell infiltration in the nasal mucosa, providing rapid symptom relief.

Mometasone furoate nasal spray is generally well tolerated, but local and systemic reactions can occur.

Common Side Effects

• Nasal irritation or burning sensation.
• Dryness of the nasal mucosa.
• Epistaxis (nosebleeds).
• Headache.
• Altered taste or throat irritation.
• Sneezing after application.

Serious or Rare Side Effects

• Severe or persistent nosebleeds.
• Vision changes or cataract formation.
• Adrenal suppression with prolonged high‑dose use.
• Allergic reactions including anaphylaxis.
• Opportunistic fungal infection of the nasal passages.
• Perforation of the nasal septum.

Before using Mometasona Aristo, consider the following safety measures.

• Prescription Use: Apply only as directed by a qualified healthcare professional.
• Hypersensitivity: Avoid if you have known allergy to mometasone or any component of the spray.
• Recent Nasal Surgery or Trauma: Use with caution and under medical supervision.
• Long‑Term Use: Monitor for signs of adrenal suppression or systemic corticosteroid effects.
• Concomitant Intranasal Steroids: Do not combine with other nasal corticosteroids without physician guidance.
• Pregnancy and Breastfeeding: Discuss potential risks with your doctor before use.
• Store at room temperature: keep in the original container, protect from moisture and direct heat.

Mometasone furoate nasal spray may interact with other medicines that affect steroid metabolism or immune function.

Major Interactions (Avoid)

• Systemic corticosteroids: increased risk of systemic glucocorticoid effects.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise local drug exposure.
• Live vaccines: potential reduction in vaccine efficacy due to immunosuppression.

Moderate Interactions (Monitor Closely)

• Moderate CYP3A4 inhibitors (e.g., erythromycin, ritonavir): may modestly increase exposure.
• Other intranasal decongestants: may heighten local irritation or dryness.