Mometasone Cristers (Mometasone Furoate Anhydrous)

• Mometasone furoate nasal spray is a topical corticosteroid used to manage inflammatory conditions of the nasal passages.
• Allergic rhinitis: relieves nasal congestion, itching, sneezing and rhinorrhea caused by seasonal or perennial allergens.
• Non‑allergic rhinitis: decreases nasal inflammation and discharge not related to allergy.
• Post‑operative nasal care: reduces swelling and crusting after nasal surgery.
• Nasal polyposis (adjunct): helps control inflammation associated with nasal polyps.

• Mometasone furoate acts as an agonist at glucocorticoid receptors in nasal epithelial cells, leading to transcriptional repression of pro‑inflammatory cytokines, chemokines and adhesion molecules. This results in decreased vascular permeability, reduced inflammatory cell infiltration, and suppression of the immune response within the nasal mucosa, providing rapid relief of swelling and irritation.

Mometasone furoate nasal spray may cause local and systemic adverse reactions.

Common Side Effects

• Nasal irritation or burning sensation.
• Headache.
• Epistaxis (nosebleeds).
• Throat irritation or dryness.
• Altered taste or bitter aftertaste.
• Cough.

Serious or Rare Side Effects

• Nasal septal perforation.
• Severe allergic reaction (anaphylaxis, angioedema).
• Vision changes such as cataracts or glaucoma.
• Systemic corticosteroid effects (adrenal suppression, hyperglycemia) with prolonged high‑dose use.
• Opportunistic infections of the nasal mucosa.

Before using Mometasone furoate nasal spray, consider the following safety measures.

• Prescription guidance: use only as directed by a qualified healthcare professional.
• Nasal infection: avoid if active bacterial, fungal or viral infection is present in the nasal cavity.
• Glaucoma or cataracts: monitor intra‑ocular pressure in patients with a history of ocular disease.
• Pregnancy and lactation: use only if the potential benefit justifies the potential risk to the fetus or infant.
• Systemic effects: limit duration and dose to reduce risk of systemic corticosteroid exposure.
• Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Mometasone furoate nasal spray can interact with other medications, affecting safety or efficacy.

Major Interactions (Avoid)

• Systemic corticosteroids: concurrent use may increase the risk of systemic corticosteroid side effects.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): may raise local drug exposure and heighten adverse effects.

Moderate Interactions (Monitor Closely)

• Nasal decongestants (oxymetazoline, phenylephrine): may increase local irritation.
• Antihistamines: additive sedation is unlikely but monitor patient comfort.
• Antiviral agents (e.g., oseltamivir): no direct interaction, but monitor for overlapping nasal symptoms.