Mometasone Eg (Mometasone Furoate)

• Mometasone furoate is a nasal corticosteroid that reduces inflammation in the upper airway.
• Allergic rhinitis: alleviates nasal congestion, itching, and sneezing caused by allergic inflammation.
• Nasal polyps: decreases polyp size and improves nasal airflow.
• Seasonal allergic rhinitis: provides symptom relief during pollen seasons.

• Mometasone furoate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses the production of pro‑inflammatory cytokines, reduces vascular permeability, and limits edema of the nasal mucosa, leading to decreased nasal inflammation and symptom relief.

Mometasone furoate may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

• Nasal irritation or burning sensation
• Epistaxis (nosebleeds)
• Headache
• Throat irritation or dryness
• Altered taste or bitter taste
• Cough

Serious or Rare Side Effects

• Adrenal suppression with prolonged high‑dose use
• Cataract formation or glaucoma
• Severe nasal septum perforation
• Opportunistic fungal infection of the nasal passages
• Systemic immunosuppression leading to increased infection risk
• Hypersensitivity reactions such as angioedema

• Before using Mometasone Eg, consider the following safety measures.
• Use only as prescribed: follow the prescriber's instructions for frequency and duration.
• Avoid use after recent nasal surgery or trauma: may impair healing.
• Monitor for signs of infection: discontinue if persistent fungal or bacterial infection develops.
• Exercise caution in children: lower systemic exposure but monitor growth with long‑term therapy.
• Limit duration of continuous use: prolonged use can increase risk of systemic effects.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Mometasone Eg can interact with other medicines that affect corticosteroid activity or metabolism.

Major Interactions (Avoid)

• Systemic corticosteroids: additive immunosuppressive effects.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase local exposure.
• Antifungal agents that inhibit glucocorticoid metabolism.

Moderate Interactions (Monitor Closely)

• Nasal decongestants: may increase local irritation.
• Antihistamines: additive sedative effect is unlikely but monitor symptom control.
• Immunosuppressants: watch for enhanced suppression of immune response.
• Live vaccines: consider timing to avoid reduced vaccine efficacy.