Mometazonă Atb (Mometasone Furoate)

Mometasone furoate is a topical corticosteroid used to manage inflammatory skin disorders.

• Atopic dermatitis: reduces redness, swelling and itching associated with eczema.
• Psoriasis: decreases plaque formation and erythema on affected skin.
• Seborrheic dermatitis: controls scaling and erythema on scalp and facial areas.

• Mometasone furoate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This interaction suppresses the expression of pro‑inflammatory cytokines, chemokines, and adhesion molecules while up‑regulating anti‑inflammatory proteins, resulting in decreased cellular infiltration and reduced inflammatory responses in the skin.

Topical application of mometasone furoate may be associated with a range of adverse reactions.

Common Side Effects

• Burning or stinging sensation at the application site.
• Skin irritation or mild erythema.
• Dryness or peeling of the treated area.
• Pruritus (itching) unrelated to the underlying condition.
• Folliculitis or acneiform eruptions.
• Telangiectasia (visible small blood vessels).

Serious or Rare Side Effects

• Skin atrophy or thinning with prolonged use.
• Hypopigmentation or depigmentation of the skin.
• Allergic contact dermatitis.
• Secondary bacterial, fungal or viral skin infections.
• Systemic adrenal suppression when large areas are treated.
• Delayed wound healing or ulceration.

When using topical mometasone furoate, certain precautions should be observed.

• Pregnancy: consult a healthcare professional before use, as safety data are limited.
• Breastfeeding: discuss potential risks with a physician, as drug may be excreted in milk.
• Broken or infected skin: avoid application unless directed by a clinician.
• Prolonged or extensive use: limit duration and surface area to reduce risk of skin atrophy.
• Concomitant topical steroids: monitor for additive corticosteroid effects.
• Store at room temperature: keep in the original container, protect from moisture and light.

Mometasone furoate may interact with other medications, altering its safety profile. Major Interactions (Avoid):\n- Systemic corticosteroids: increased risk of systemic glucocorticoid effects.

• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise local drug exposure.
• Antifungal agents applied to the same area: potential additive irritation.

Moderate Interactions (Monitor Closely)

• Photosensitizing drugs (e.g., tetracyclines): heightened risk of sunburn.
• Retinoids (topical or oral): may increase skin irritation.
• Immunosuppressants: monitor for signs of infection due to combined immunosuppressive action.