Mometasone Inteli (Mometasone Furoate Monohydrate)

Mometasone Inteli is a topical corticosteroid that acts on inflammatory processes of the nasal mucosa.

• Allergic rhinitis: alleviates nasal congestion, sneezing and itching caused by seasonal or perennial allergens.
• Nasal polyps: reduces polyp size and associated blockage, improving nasal breathing.
• Chronic rhinosinusitis with nasal polyps: helps control inflammation and prevents recurrence of polyps after surgical removal.

• Mometasone furoate binds to intracellular glucocorticoid receptors in nasal epithelial cells, forming a receptor complex that translocates to the nucleus. This complex modulates gene transcription, suppressing pro‑inflammatory cytokines, chemokines and adhesion molecules, while enhancing anti‑inflammatory proteins. The result is decreased vascular permeability, edema, and immune cell infiltration in the nasal mucosa.

Mometasone Inteli may cause local and systemic adverse reactions.

Common Side Effects

• Nasal irritation or burning sensation: mild discomfort at the application site.
• Epistaxis (nosebleeds): occasional bleeding due to mucosal dryness.
• Headache: transient headache reported by some users.
• Sore throat or cough: irritation of the upper airway.
• Altered taste or smell: temporary changes in sensory perception.

Serious or Rare Side Effects

• Nasal septal perforation: rare tissue damage requiring medical attention.
• Cataracts or glaucoma: potential increase in intra‑ocular pressure with prolonged use.
• Adrenal suppression: systemic effects from excessive absorption.
• Fungal infection of the nasal passages: opportunistic infection in immunocompromised individuals.

Before using Mometasone Inteli, consider the following precautions.

• Pregnancy: consult a healthcare professional as safety data are limited.
• Breastfeeding: discuss potential risks with a physician before use.
• Elderly patients: monitor for systemic corticosteroid effects, especially with long‑term therapy.
• Untreated fungal infection: avoid use until infection is resolved to prevent spread.
• Duration of therapy: do not exceed prescribed treatment period without medical review.
• Store at room temperature: keep in the original container, protect from moisture and direct heat.

Mometasone Inteli can interact with other medications that affect corticosteroid activity or metabolism.

Major Interactions (Avoid)

• Systemic corticosteroids: concurrent use may increase risk of systemic side effects.
• Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise local drug concentrations.

Moderate Interactions (Monitor Closely):\n- Antifungal azoles (e.g., itraconazole): potential increase in exposure.

• Live vaccines: intranasal steroids may reduce vaccine efficacy.
• Nasal decongestants: combined use may increase local irritation.