Mometasone Sandoz (Mometasone Furoate)

Mometasone Sandoz is a topical corticosteroid that acts on the nasal mucosa to reduce inflammation in the following conditions:

• Allergic rhinitis: relieves nasal congestion, itching, sneezing and rhinorrhea.
• Nasal polyps: decreases polyp size and improves nasal airflow.
• Seasonal allergic rhinitis: controls symptoms triggered by seasonal allergens.

• Mometasone furoate binds to intracellular glucocorticoid receptors in nasal epithelial cells, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses the production of pro‑inflammatory cytokines, reduces vascular permeability, and inhibits immune cell activation, leading to decreased nasal mucosal inflammation.

Mometasone Sandoz may cause local and systemic adverse reactions. Most are mild and reversible.

Common Side Effects

• Nasal irritation or burning sensation.
• Headache.
• Epistaxis (nosebleed).
• Throat irritation or dryness.
• Altered taste or bitter taste.
• Cough.

Serious or Rare Side Effects

• Nasal septal perforation.
• Severe allergic reaction (anaphylaxis).
• Adrenal suppression with prolonged high‑dose use.
• Vision changes such as cataracts or glaucoma.
• Opportunistic fungal infection of the nasal passages.
• Persistent hoarseness or vocal cord changes.

Before using Mometasone Sandoz, consider the following safety measures:

• Prescription only: use exactly as directed by a healthcare professional.
• Avoid use in untreated bacterial, viral, or fungal nasal infections.
• Monitor for signs of adrenal insufficiency during long‑term therapy.
• Caution in patients with glaucoma or cataracts.
• Discontinue if hypersensitivity to mometasone or any excipients occurs.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Mometasone Sandoz can interact with other medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

• Systemic corticosteroids: additive risk of systemic glucocorticoid effects.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase local exposure.

Moderate Interactions (Monitor Closely)

• Antihistamines: may mask nasal irritation symptoms.
• Nasal decongestants: combined use can increase local pressure.
• Antifungal agents: potential for altered local flora.
• Immunosuppressants: heightened risk of infection.
• Vaccines administered intranasally: possible reduced efficacy.