Mometasone Target (Mometasone Furoate)

Mometasone furoate is a topical corticosteroid used to manage inflammatory skin disorders.

• Psoriasis: reduces erythema, scaling, and plaque thickness, leading to smoother skin.
• Atopic dermatitis (eczema): alleviates itching, redness and inflammation, improving skin barrier function.
• Allergic contact dermatitis: diminishes swelling and itching caused by allergen exposure, promoting faster healing.
• Seborrheic dermatitis: controls flaking, redness and irritation on the scalp and facial areas.
• Lichen planus: lessens lesion size and associated discomfort, aiding symptom relief.

• Mometasone furoate binds to intracellular glucocorticoid receptors in keratinocytes and immune cells. The drug‑receptor complex moves to the nucleus and modulates gene transcription, suppressing pro‑inflammatory cytokines such as IL‑1, IL‑6 and TNF‑α while up‑regulating anti‑inflammatory proteins, thereby reducing leukocyte infiltration, vasodilation and edema in the skin.

Topical application of mometasone furoate may be associated with local and systemic adverse reactions.

Common Side Effects

• Burning or stinging at the site.
• Skin dryness or peeling.
• Local itching or erythema.

Serious or Rare Side Effects

• Skin atrophy or thinning.
• Telangiectasia.
• Secondary infection (bacterial, fungal, viral).

When using topical mometasone furoate, several precautions should be observed to minimize risks.

• Duration of use: limit application to the shortest effective period, typically no longer than 2‑4 weeks on sensitive areas.
• Application area: avoid use on broken skin, open wounds or infected lesions unless directed by a clinician.
• Age restrictions: use with caution in children; pediatric dosing should be determined by a healthcare professional.
• Systemic absorption: avoid extensive body‑surface coverage to reduce risk of systemic corticosteroid effects.
• Concomitant therapy: do not combine with other potent topical steroids without medical advice.
• Store at ambient temperature: keep below 25 °C, protect from moisture and direct sunlight in the original container.

Mometasone furoate can interact with other agents applied to the skin or systemic drugs that affect corticosteroid metabolism.

Major Interactions (Avoid)

• Systemic corticosteroids: concurrent use may increase risk of systemic side effects such as adrenal suppression.
• CYP3A4 inhibitors (e.g., ketoconazole) applied topically: may raise local steroid concentration.

Moderate Interactions (Monitor Closely)

• Antifungal or antibacterial creams: may alter skin barrier and affect absorption.
• Immunosuppressants (e.g., cyclosporine): monitor for enhanced immunosuppression.
• Phototherapy: increased risk of skin thinning when combined with potent topical steroids.