Mometasone Teva (Mometasone Furoate)

Mometasone Teva, a nasal corticosteroid, is used to manage inflammatory conditions of the nasal passages.

• Allergic rhinitis: reduces nasal congestion, itching, and sneezing caused by allergens.
• Seasonal allergic rhinitis: alleviates symptoms triggered by seasonal pollen exposure.
• Perennial allergic rhinitis: controls year‑round nasal inflammation from indoor allergens.
• Nasal polyps: decreases polyp size and improves nasal airflow in affected patients.

• Mometasone furoate binds to intracellular glucocorticoid receptors in nasal epithelial cells, forming a receptor complex that translocates to the nucleus. This complex interacts with glucocorticoid response elements, modulating gene transcription to suppress pro‑inflammatory cytokines, chemokines, and adhesion molecules, thereby reducing inflammatory cell infiltration and edema in the nasal mucosa. The localized action minimizes systemic exposure while providing effective anti‑inflammatory control.

Mometasone Teva may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

• Nasal irritation or burning sensation
• Dryness of the nasal mucosa
• Sneezing
• Epistaxis (nosebleeds)
• Headache
• Throat irritation

Serious or Rare Side Effects

• Nasal septal perforation
• Severe allergic reaction (anaphylaxis)
• Vision changes or cataract formation
• Elevated intra‑ocular pressure
• Suppression of adrenal function
• Opportunistic fungal infection of the nasal passages

Before prescribing Mometasone Teva, clinicians should consider several precautionary measures to ensure safe use.

• Indicated age: use only in patients aged 12 years and older unless otherwise directed.
• Local infection: avoid use in presence of untreated bacterial, fungal, or viral nasal infections.
• Surgery: discontinue several days before nasal or sinus surgery to reduce bleeding risk.
• Systemic steroid use: monitor for additive glucocorticoid effects when combined with oral steroids.
• Pregnancy and lactation: assess risk–benefit as safety data are limited.
• Store at room temperature: keep below 25 °C, in original container, protected from moisture and direct sunlight.

Mometasone Teva can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure and risk of adrenal suppression.
• Systemic immunosuppressants (e.g., cyclosporine): heightened risk of infection.

Moderate Interactions (Monitor Closely)

• Antifungal azoles (e.g., fluconazole): may modestly raise mometasone levels.
• Ritonavir or other protease inhibitors: potential increase in glucocorticoid activity.
• Nasal decongestants (e.g., oxymetazoline): may cause additive nasal irritation.
• Live vaccines: reduced vaccine efficacy due to immunosuppression.