Mometasone Viatris (Mometasone Furoate)

• Mometasone furoate nasal spray acts on inflammatory pathways of the nasal mucosa to relieve symptoms of allergic and obstructive nasal conditions.
• Allergic rhinitis: alleviates nasal congestion, itching, sneezing and watery discharge, providing rapid symptom control in seasonal and perennial allergy sufferers.
• Nasal polyps: reduces polyp size and associated inflammation, leading to improved nasal patency and decreased need for surgical intervention.

• Mometasone furoate binds to intracellular glucocorticoid receptors in nasal epithelial cells, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses the production of pro‑inflammatory cytokines, chemokines and adhesion molecules, while enhancing anti‑inflammatory proteins. The resulting effect is a marked reduction of local inflammation, edema and mucus secretion within the nasal mucosa. Because systemic absorption is minimal, the anti‑inflammatory effect remains largely confined to the nasal cavity.

Mometasone furoate nasal spray may cause local and, rarely, systemic adverse reactions.

Common Side Effects

• Nasal irritation or burning sensation
• Epistaxis (nosebleeds)
• Headache
• Throat irritation or dryness
• Cough
• Altered taste perception

Serious or Rare Side Effects

• Adrenal suppression with prolonged high‑dose use
• Severe nasal septal perforation
• Vision changes or cataract formation
• Opportunistic fungal infection of the nasal passages
• Anaphylaxis or severe allergic reaction
• Growth suppression in pediatric patients

• Before initiating therapy, consider the following precautions.
• Screen for active nasal infection: avoid use in untreated bacterial or fungal sinusitis.
• Monitor for adrenal effects: assess for signs of systemic corticosteroid exposure, especially with prolonged use.
• Use with caution in children: monitor growth velocity during therapy.
• Avoid abrupt discontinuation: taper dose to prevent rebound inflammation.
• Assess for hypersensitivity: discontinue if allergic reaction occurs.
• Store at room temperature: keep in original packaging, protect from moisture and heat.

Mometasone furoate nasal spray can interact with other medicines; review the following.

Major Interactions (Avoid)

• Systemic corticosteroids: concurrent use may increase risk of systemic glucocorticoid effects.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise local mometasone exposure.

Moderate Interactions (Monitor Closely)

• Antihistamines: may increase local irritation but are generally safe.
• Nasal decongestant sprays: concurrent use may affect mucosal absorption.
• Immunosuppressants: monitor for additive immunosuppression.
• Ritonavir: potential increase in corticosteroid levels.