Product image of Mometasone Zentiva (Mometasone Furoate Monohydrate) supplied by GNH India

Mometasone Zentiva

Active Ingredient:
Mometasone Furoate Monohydrate
Origin:
EU

Mometasone Zentiva (Mometasone Furoate Monohydrate)

Mometasone furoate monohydrate, the active ingredient in Mometasone Zentiva, is a corticosteroid presented as a nasal spray for intranasal use. It reduces nasal inflammation and is indicated for allergic rhinitis and other nasal inflammatory conditions.

GNH India supplies Mometasone Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Mometasone furoate is a nasal corticosteroid that acts on the inflammatory pathway of the nasal mucosa.

  • Allergic rhinitis: provides relief of nasal congestion, itching, sneezing and rhinorrhoea.
  • Nasal polyposis (post‑surgical): helps prevent recurrence of polyps after sinus surgery.
  • Non‑allergic rhinitis: reduces nasal inflammation and improves airflow.

How It Works

  • Mometasone furoate monohydrate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses the production of pro‑inflammatory cytokines, chemokines and adhesion molecules, leading to reduced vascular permeability and inhibition of immune cell activation in the nasal mucosa.

Side Effects

Mometasone furoate nasal spray may cause local and systemic adverse reactions.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Headache.
  • Epistaxis (nosebleed).
  • Throat irritation or cough.
  • Altered taste or oral dryness.

Serious or Rare Side Effects

  • Adrenal suppression with prolonged high‑dose use.
  • Fungal infection of the nasal passages.
  • Severe allergic reaction (anaphylaxis).
  • Vision changes or ocular pressure increase.
  • Nasal septum perforation.

Precautions & Warnings

Before using Mometasone Zentiva, consider the following precautions.

  • Pregnancy: consult a healthcare professional before initiating therapy.
  • Breastfeeding: discuss potential risks with a physician.
  • Active nasal infection: avoid use until the infection is resolved.
  • Upcoming nasal or sinus surgery: discontinue the spray as advised by the surgeon.
  • Long‑term therapy: monitor for signs of adrenal suppression.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mometasone furoate may interact with other medicines; review the following categories.

Major Interactions (Avoid)

  • Systemic corticosteroids: increased risk of systemic glucocorticoid effects.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise local drug exposure.
  • Live vaccines: nasal corticosteroid may diminish vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Antifungal nasal sprays: may increase local irritation.
  • Antihistamines: additive sedative effect is unlikely but monitor symptoms.
  • Immunosuppressants: watch for heightened infection risk.

Frequently Asked Questions

Mometasone Zentiva is a nasal spray containing mometasone furoate, a corticosteroid used to treat inflammatory nasal conditions such as allergic rhinitis, non‑allergic rhinitis, and to help prevent recurrence of nasal polyps after sinus surgery.

Mometasone furoate binds to glucocorticoid receptors in nasal mucosal cells, altering gene transcription to suppress the release of inflammatory cytokines, chemokines and other mediators. This reduces swelling, mucus production and the overall inflammatory response in the nasal passages.

The appropriate dose and dosing schedule are determined by the prescribing healthcare professional based on the patient’s condition, age and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for mometasone furoate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mometasone furoate is a high‑potency nasal corticosteroid with a low systemic bioavailability, similar to fluticasone propionate. Compared with some alternatives, it may provide effective symptom control at once‑daily dosing, but the choice of agent depends on individual patient response, tolerability and prescriber preference.

Store the nasal spray at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, excessive heat and direct sunlight. Do not freeze the product, and ensure the cap is tightly closed when not in use.

The spray is intended for intranasal use. The patient should gently blow the nose, insert the tip into one nostril, close the opposite nostril, and spray the prescribed number of actuations while breathing in gently. The process is repeated in the other nostril if directed by the prescriber.

Serious risks, although rare, include adrenal suppression with prolonged high‑dose use, fungal infections of the nasal passages, severe allergic reactions such as anaphylaxis, and structural damage like nasal septum perforation. Patients should report any unusual symptoms promptly to their healthcare provider.

Individuals with known hypersensitivity to mometasone furoate or any component of the formulation should avoid the product. It is also contraindicated in patients with active untreated nasal infections, recent nasal surgery without physician approval, or those for whom systemic corticosteroid exposure is contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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