Product image of Mometasone Zentiva (Mometasone Furoate Monohydrate) supplied by GNH India

Mometasone Zentiva

Active Ingredient:
Mometasone Furoate Monohydrate
Origin:
EU

Mometasone Zentiva (Mometasone Furoate Monohydrate)

Mometasone furoate, the active ingredient in Mometasone Zentiva, is a corticosteroid presented as a nasal spray for intranasal use. It reduces inflammation in the nasal passages and is indicated for allergic rhinitis, seasonal allergic rhinitis and nasal polyps in adults and children and is suitable for both seasonal and perennial symptoms.

GNH India supplies Mometasone Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Zentiva France

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Indications & Clinical Uses

  • Mometasone furoate nasal spray is used to treat inflammatory conditions of the nasal mucosa.
  • Allergic rhinitis: relieves nasal congestion, itching and sneezing caused by allergic inflammation.
  • Seasonal allergic rhinitis: controls symptoms triggered by pollen or seasonal allergens.
  • Nasal polyps: reduces polyp size and improves nasal airflow.

How It Works

  • Mometasone furoate binds to intracellular glucocorticoid receptors in nasal epithelial cells, forming a complex that translocates to the nucleus and modulates gene transcription. This down‑regulates pro‑inflammatory cytokines, chemokines and adhesion molecules, leading to decreased vascular permeability, edema and immune cell infiltration in the nasal mucosa. The localized action limits systemic exposure while providing potent anti‑inflammatory effects within the nasal passages.

Side Effects

Mometasone furoate nasal spray may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Epistaxis (nosebleeds).
  • Headache.
  • Sore throat or cough.
  • Altered taste or unpleasant odor.
  • Dryness of the nasal mucosa.

Serious or Rare Side Effects

  • Adrenal suppression with prolonged use.
  • Fungal infection of the nasal passages.
  • Severe or persistent nosebleeds.
  • Vision changes or secondary glaucoma.
  • Systemic immunosuppression leading to increased infection risk.
  • Hypersensitivity reactions such as angioedema.

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Pregnancy: consult a healthcare professional before use, as safety data are limited.
  • Breastfeeding: discuss risks with a physician, as the drug may be excreted in milk.
  • Elderly patients: monitor for systemic effects due to possible reduced metabolism.
  • Long‑term use: assess hypothalamic‑pituitary‑adrenal axis function periodically.
  • Concomitant nasal surgery: postpone treatment until healing is complete.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Mometasone furoate may interact with other medicines; review the following categories.

Major Interactions (Avoid)

  • Systemic corticosteroids: concurrent use may increase risk of systemic glucocorticoid effects.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): may raise local drug exposure leading to increased adverse effects.

Moderate Interactions (Monitor Closely)

  • Antifungal agents (e.g., itraconazole): may modestly increase exposure.
  • Live vaccines: nasal corticosteroid may reduce vaccine efficacy.
  • Nasal decongestants: combined use may increase local irritation.

Frequently Asked Questions

Mometasone Zentiva is a prescription nasal spray containing mometasone furoate. It is used to treat inflammatory nasal conditions such as allergic rhinitis, seasonal allergic rhinitis, and nasal polyps by reducing swelling, congestion, and other allergy‑related symptoms.

Mometasone furoate binds to glucocorticoid receptors in the cells lining the nasal passages. This binding alters gene expression, suppressing the production of inflammatory mediators and decreasing immune‑cell infiltration, which leads to reduced nasal inflammation and symptom relief.

The exact dose is determined by the prescribing clinician based on the patient’s age, severity of symptoms, and response to therapy. Typical regimens involve one or two sprays per nostril once daily, but the prescriber sets the final dosing schedule.

Safety data for mometasone furoate in pregnancy are limited, so it should only be used if the potential benefit outweighs any risk. During breastfeeding, the drug may be present in milk; mothers should discuss possible risks with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mometasone furoate is a high‑potency intranasal corticosteroid with a low systemic bioavailability, offering strong local anti‑inflammatory effects while minimizing systemic exposure. Compared with agents such as fluticasone or budesonide, it provides comparable efficacy with a similar safety profile, though individual response may vary.

Store the nasal spray at ambient temperature, preferably below 25 °C, in its original packaging. Protect it from moisture, direct sunlight and extreme heat. Keep the device upright and avoid freezing. Do not share the product with others.

The spray is administered directly into each nostril. Before use, gently shake the bottle, prime it if required, and tilt the head slightly forward. Insert the tip into a nostril, close the opposite nostril, and press the actuator to deliver the prescribed number of sprays. Avoid blowing the nose immediately after administration.

Serious risks, though rare, include adrenal suppression with prolonged high‑dose use, fungal infections of the nasal mucosa, severe nosebleeds, and systemic immunosuppression that could increase susceptibility to infections. Patients should report persistent bleeding, visual changes, or signs of infection to their healthcare provider promptly.

Mometasone Zentiva should be avoided in individuals with known hypersensitivity to mometasone furoate or any component of the formulation. It is also contraindicated in patients with active, untreated fungal infections of the nasal passages or those who have recently undergone nasal surgery without medical clearance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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