Mometasonfuroat Abz (Mometasone Furoate)

Mometasone furoate nasal spray acts on inflammatory pathways of the nasal mucosa to treat allergic and inflammatory nasal conditions.

• Allergic rhinitis: reduces nasal congestion, itching, sneezing and rhinorrhea associated with seasonal or perennial allergens.
• Nasal polyps: decreases polyp size and improves nasal airflow after surgical removal or in chronic cases.
• Non‑allergic rhinitis: alleviates nasal symptoms caused by irritants or vasomotor instability.

• Mometasone furoate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses the production of pro‑inflammatory cytokines, chemokines, and adhesion molecules, while enhancing anti‑inflammatory proteins. The resulting inhibition of inflammatory cell recruitment and mediator release reduces edema and mucus secretion in the nasal passages. Consequently, nasal tissue swelling and hyperreactivity are markedly decreased.

Mometasone furoate nasal spray may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

• Nasal irritation or burning sensation.
• Dryness of the nasal mucosa.
• Epistaxis (nosebleeds).
• Headache.
• Sore throat.
• Cough.

Serious or Rare Side Effects

• Nasal septal perforation.
• Cataracts or increased intra‑ocular pressure (glaucoma).
• Adrenal suppression with systemic effects.
• Severe allergic reaction (anaphylaxis).
• Fungal infection of the nasal passages.
• Prolonged use leading to systemic corticosteroid effects.

Before initiating therapy with Mometasone furoate nasal spray, consider the following precautions to ensure safe and effective use.

• Screen for nasal infection: avoid use if active bacterial, viral or fungal infection is present.
• Assess hypersensitivity: discontinue if patient experiences rash, swelling or other allergic signs.
• Use lowest effective dose: limit duration to the recommended period to reduce systemic exposure.
• Monitor for systemic corticosteroid effects: watch for signs of adrenal suppression, growth retardation in children, or bone density loss.
• Avoid concurrent intranasal or systemic steroids unless medically justified.
• Store at room temperature: keep in original container, protect from moisture and heat.

Mometasone furoate nasal spray can interact with other medicines, affecting its safety or efficacy.

Major Interactions (Avoid)

• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure and risk of adrenal suppression.
• Concurrent use of other intranasal or systemic corticosteroids: can amplify systemic glucocorticoid effects.

Moderate Interactions (Monitor Closely)

• Ritonavir or other protease inhibitors: may modestly raise mometasone levels; monitor for side effects.
• Immunosuppressants (e.g., azathioprine, cyclosporine): may increase risk of infection; observe patient.
• Warfarin: potential alteration of anticoagulant effect; check INR periodically.