Product image of Monast (Montelukast) supplied by GNH India

Monast

Active Ingredient:
Montelukast
Origin:
EU

Monast (Montelukast)

Montelukast, the active ingredient in Monast, is a leukotriene receptor antagonist presented as an oral dosage form for oral use. It treats asthma, allergic rhinitis and exercise‑induced bronchoconstriction in adults and children as directed by a healthcare professional.

GNH India supplies Monast as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Genetic Spa

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Indications & Clinical Uses

Montelukast is a leukotriene receptor antagonist used to manage conditions involving airway inflammation.

  • Asthma: improves long‑term control and reduces the frequency of exacerbations.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing triggered by physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 from binding. This inhibition reduces leukotriene‑mediated bronchoconstriction, vascular permeability, and inflammatory cell recruitment in the airways, thereby improving respiratory function and decreasing allergic inflammation.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Abdominal pain: occasional discomfort.
  • Cough: transient irritation.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or throat requiring urgent care.
  • Stevens‑Johnson syndrome: severe skin reactions.
  • Hepatic injury: elevated liver enzymes or jaundice.
  • Mood changes: rare reports of depression or suicidal thoughts.

Precautions & Warnings

When prescribing Montelukast, clinicians should consider several safety aspects.

  • Pregnancy: Category B; use only if the benefit outweighs potential risk.
  • Breastfeeding: monitor infant for possible effects; benefits usually outweigh risks.
  • Liver impairment: dose adjustment may be needed; monitor hepatic function.
  • Concomitant enzyme inducers (e.g., rifampin, phenobarbital): may reduce efficacy.
  • Hypersensitivity: avoid in patients with known allergy to montelukast or its excipients.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Avoid Interactions

Montelukast may interact with other medicines, requiring attention to avoid reduced effectiveness or increased toxicity.

Major Interactions (Avoid)

  • Rifampin: induces metabolism, lowering montelukast plasma levels.
  • Phenobarbital: enzyme induction may diminish therapeutic effect.
  • Ketoconazole: strong CYP3A inhibition can raise montelukast concentrations.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR; monitor coagulation.
  • Beta‑agonists: additive bronchodilation may enhance symptom relief.
  • ACE inhibitors: combined use may increase cough frequency.

Frequently Asked Questions

Monast contains montelukast, which is prescribed to manage asthma, allergic rhinitis and exercise‑induced bronchoconstriction. It helps control chronic airway inflammation, reduces nasal symptoms, and prevents bronchospasm triggered by physical activity, improving overall respiratory health.

Montelukast blocks the CysLT1 receptor, a binding site for cysteinyl leukotrienes such as leukotriene D4. By preventing these mediators from activating the receptor, it reduces bronchoconstriction, mucus production, and inflammatory cell recruitment in the airways, leading to better breathing and fewer allergy symptoms.

The specific dose of Monast is determined by the prescribing clinician based on the patient’s age, weight, condition severity and other medical factors. Healthcare providers follow approved dosing guidelines and adjust as needed for optimal therapeutic effect.

Montelukast is classified as Pregnancy Category B, indicating no evidence of risk in animal studies and limited human data. It may be used during pregnancy if the potential benefit justifies any risk. While it passes into breast milk in small amounts, breastfeeding is generally considered acceptable with clinical monitoring.

To request Monast, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Monast (montelukast) belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is especially useful for patients who prefer a once‑daily tablet, have difficulty using inhalers, or need additional control of allergic rhinitis alongside asthma.

Monast should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Monast is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious but rare risks include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, hepatic injury, and neuropsychiatric events like mood changes or suicidal thoughts. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, jaundice, or significant changes in mood.

Monast is contraindicated in individuals with a known hypersensitivity to montelukast or any of its excipients. Caution is advised for patients with severe liver disease, and it should be avoided in those taking strong enzyme‑inducing drugs that may markedly reduce its effectiveness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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