Product image of Moniyot-131 (Sodium Iodide (131i)) supplied by GNH India

Moniyot-131

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Moniyot-131 (Sodium Iodide (131i))

Sodium Iodide I-131, the active ingredient in Moniyot-131, is a radiopharmaceutical presented as a oral solution for oral use. It treats hyperthyroidism, thyroid cancer and post‑surgical thyroid ablation by selectively destroying thyroid tissue.
GNH India supplies Moniyot-131 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Monrol Europe Srl

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Indications & Clinical Uses

  • Moniyot-131 is used in thyroid‑targeted therapy to manage conditions that involve excess or malignant thyroid tissue.
  • Hyperthyroidism: reduces hormone production by ablating overactive thyroid cells.
  • Thyroid cancer: destroys residual cancer cells after surgery.
  • Post‑surgical thyroid ablation: eliminates remaining thyroid tissue to facilitate further radioactive iodine treatment.

How It Works

  • Sodium Iodide I-131 is actively taken up by thyroid cells via the sodium‑iodide symporter. Once inside, the isotope emits beta particles that cause localized cellular damage and ablation, while accompanying gamma emissions allow imaging of iodine distribution within the gland.

Side Effects

Adverse reactions to Moniyot-131 may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal discomfort.
  • Salivary gland swelling: transient enlargement and tenderness.
  • Dry mouth: reduced salivary flow.
  • Taste alteration: temporary metallic taste.

Serious or Rare Side Effects

  • Bone marrow suppression: decreased blood cell counts, increasing infection or bleeding risk.
  • Radiation thyroiditis: painful inflammation of thyroid tissue.
  • Pulmonary fibrosis: rare lung scarring after high cumulative doses.

Precautions & Warnings

Moniyot-131 requires careful consideration of several safety factors.

  • Pregnancy: contraindicated; category X due to fetal radiation exposure.
  • Breastfeeding: not recommended; iodine may be secreted in milk.
  • Thyroid function testing: perform baseline and periodic assessments.
  • Antithyroid medications: discontinue before administration to avoid reduced uptake.
  • Renal impairment: evaluate iodine clearance and adjust monitoring.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light in the original container.

Avoid Interactions

Moniyot-131 may interact with other medicines that affect iodine uptake or clearance.

Major Interactions (Avoid)

  • Lithium: reduces radioactive iodine uptake, diminishing efficacy.
  • Amiodarone: high iodine content interferes with treatment outcomes.
  • Antithyroid drugs (methimazole, propylthiouracil): block iodine uptake; should be stopped prior.

Moderate Interactions (Monitor Closely)

  • Calcium supplements: may decrease absorption if taken simultaneously.
  • Iron preparations: can reduce iodine uptake; separate dosing by several hours.
  • Diuretics (thiazides): may alter renal clearance of iodine.

Frequently Asked Questions

Moniyot-131 is a radiopharmaceutical containing Sodium Iodide I-131 that is used to treat hyperthyroidism, eradicate residual thyroid cancer cells after surgery, and perform post‑surgical thyroid ablation to remove remaining thyroid tissue.

The sodium‑iodide symporter in thyroid cells actively transports Sodium Iodide I-131 into the gland. The isotope then emits beta particles that cause localized cellular destruction, while gamma emissions enable imaging of iodine distribution.

The prescribed dose of Moniyot-131 is individualized by the treating physician based on factors such as the specific indication, thyroid size, uptake studies, patient weight, and prior treatments. No standard dose is provided here.

Moniyot-131 is classified as pregnancy category X because the radioactive iodine can harm the developing fetus. It is also not recommended during breastfeeding, as iodine may be secreted in breast milk and expose the infant.

To order Moniyot-131, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Moniyot-131 is comparable to other I‑131 preparations in its mechanism of selective thyroid uptake and beta‑particle emission. Differences may lie in formulation, regulatory approvals, and supplier certifications. GNH India offers an EU‑licensed oral solution that meets Good Distribution Practice standards.

Moniyot-131 should be stored at ambient temperature, preferably below 25 °C, in its original sealed container. Protect the solution from moisture, direct sunlight, and physical damage. Follow all local radiation safety regulations when handling the product.

Moniyot-131 is supplied as an oral solution that is taken by mouth under the supervision of a qualified healthcare professional. The exact administration protocol, including fasting status and timing relative to other medications, is determined by the prescribing clinician.

Serious risks include bone marrow suppression, which can lead to anemia, infection or bleeding; radiation thyroiditis causing painful inflammation of the gland; and, in rare cases, pulmonary fibrosis after high cumulative doses. Patients should be monitored closely for these events.

Moniyot-131 should not be used by pregnant or breastfeeding women, individuals with known hypersensitivity to iodine or sodium iodide, patients with severe renal impairment without appropriate monitoring, and those who have not discontinued antithyroid drugs that block iodine uptake.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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