Product image of Moniyot-131 (Sodium Iodide (131i)) supplied by GNH India

Moniyot-131

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Moniyot-131 (Sodium Iodide (131i))

Sodium Iodide-131, the active ingredient in Moniyot-131, is a radiopharmaceutical presented as an oral solution for oral use. It treats thyroid disease such as hyperthyroidism, thyroid cancer, and benign thyroid nodules by delivering targeted radiation to thyroid tissue.

GNH India supplies Moniyot-131 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Monrol Europe Srl

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Indications & Clinical Uses

Moniyot-131 is used in the management of thyroid disorders that take up iodine via the sodium‑iodide symporter.

  • Hyperthyroidism: reduces excess thyroid hormone production by ablating overactive thyroid tissue.
  • Thyroid cancer (adjuvant ablation): destroys residual thyroid cells after surgery to lower recurrence risk.
  • Benign thyroid nodules: shrinks nodular tissue that demonstrates iodine uptake.
  • Diagnostic imaging of thyroid tissue: provides functional imaging to assess thyroid tissue distribution.

How It Works

  • Sodium Iodide-131 is taken up by thyroid cells through the sodium‑iodide symporter (NIS). Once inside the gland, the isotope emits beta particles that cause localized cellular damage, leading to selective destruction of thyroid tissue while sparing surrounding structures.

Side Effects

Adverse reactions to Moniyot-131 may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Salivary gland irritation: transient swelling or discomfort.
  • Dry mouth: reduced salivary flow.
  • Fatigue: temporary feeling of tiredness.

Serious or Rare Side Effects

  • Bone marrow suppression: decreased blood cell production.
  • Severe hypothyroidism: excessive loss of thyroid function requiring hormone replacement.
  • Radiation‑induced secondary malignancies: rare risk of new cancers.

Precautions & Warnings

When using Moniyot-131, several safety considerations should be observed.

  • Pregnancy: avoid use unless benefits outweigh risks, as fetal thyroid may be affected.
  • Breastfeeding: discontinue breastfeeding during treatment and for a period afterward.
  • Renal impairment: adjust monitoring because iodine clearance may be reduced.
  • Concomitant thyroid hormone therapy: assess need for dose adjustments after ablation.
  • Radiation safety: ensure proper handling and limit exposure to staff and family members.
  • Store at ambient temperature: keep below 25°C in original container, protect from moisture and light.

Avoid Interactions

Moniyot-131 can interact with other agents that affect thyroid function or radiation exposure.

Major Interactions (Avoid)

  • Antithyroid drugs (e.g., methimazole, propylthiouracil): may reduce uptake of radioiodine, diminishing therapeutic effect.
  • High‑iodine diet or iodine‑containing contrast agents: compete for NIS, lowering efficacy.

Moderate Interactions (Monitor Closely)

  • Levothyroxine: dose may need adjustment after ablation.
  • Chemotherapeutic agents causing bone marrow suppression: increased risk of hematologic toxicity.
  • Salivary stimulants (e.g., pilocarpine): may exacerbate salivary gland irritation.

Frequently Asked Questions

Moniyot-131 is a prescription oral solution of Sodium Iodide-131 used to treat thyroid conditions that absorb iodine, including hyperthyroidism, as an adjuvant therapy after thyroid cancer surgery, and benign thyroid nodules. It is also employed for diagnostic imaging to evaluate functional thyroid tissue.

Sodium Iodide-131 is selectively taken up by thyroid cells via the sodium‑iodide symporter. Inside the cells, the isotope emits beta radiation that damages cellular DNA, leading to targeted destruction of thyroid tissue while minimizing impact on surrounding organs.

The prescribed dose of Moniyot-131 is individualized by the treating physician based on factors such as the patient’s thyroid uptake studies, disease severity, body weight, and intended therapeutic goal. No standard dosing regimen is provided publicly.

Safety data are limited; Moniyot-131 may cross the placenta and affect fetal thyroid development, and it can be secreted in breast milk. Use is generally avoided unless the potential benefit justifies the risk, and breastfeeding should be paused during and after treatment as advised by a clinician.

To order Moniyot-131, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Moniyot-131 is chemically identical to other Sodium Iodide‑131 preparations but is supplied as an oral solution meeting EU quality standards. Compared with older formulations, it offers comparable efficacy and safety, with the advantage of a controlled manufacturing process and reliable potency.

Moniyot-131 should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect the solution from moisture, direct sunlight and physical damage. Handling must follow radiation safety guidelines, including the use of appropriate shielding and protective equipment.

Moniyot-131 is administered orally as a single dose of the prescribed volume of the solution. The patient typically ingests the dose under medical supervision, and post‑administration instructions include hydration, avoiding close contact with pregnant individuals, and monitoring for side effects.

The most serious risks include bone marrow suppression, which can lead to anemia or infection, severe hypothyroidism requiring lifelong hormone replacement, and the rare possibility of radiation‑induced secondary malignancies. Patients should be monitored regularly for blood counts and thyroid function.

Moniyot-131 is contraindicated in patients with known hypersensitivity to iodine or radioactive iodine, those who are pregnant or breastfeeding unless absolutely necessary, and individuals with uncontrolled severe renal impairment that could impede iodine clearance. Clinical judgment is essential for each case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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