Product image of Moniyot-131 (Sodium Iodide (131i)) supplied by GNH India

Moniyot-131

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Moniyot-131 (Sodium Iodide (131i))

Sodium Iodide (131I), the active ingredient in Moniyot-131, is a radioisotope presented as a diagnostic radiopharmaceutical for oral use. It belongs to the therapeutic class of thyroid imaging and therapy agents and is selectively taken up by thyroid tissue, enabling both functional imaging and delivery of beta radiation for therapeutic ablation in hyperthyroidism and thyroid cancer.

GNH India supplies Moniyot-131 as a licensed, GDP‑compliant international pharmaceutical supplier, sourcing the product from EU manufacturers and serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Monrol Europe Srl

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Indications & Clinical Uses

Moniyot-131 is employed in the thyroid pathway for both diagnostic imaging and therapeutic ablation.

  • Thyroid imaging: Provides functional visualization of thyroid uptake, aiding assessment of gland activity and detection of nodular lesions.
  • Hyperthyroidism treatment: Delivers targeted beta radiation to overactive thyroid tissue, reducing hormone production in conditions such as Graves’ disease.
  • Thyroid cancer ablation: Used post‑thyroidectomy to eradicate residual thyroid cells, decreasing recurrence risk.
  • Thyroid nodule evaluation: Helps differentiate autonomous nodules from malignant lesions by measuring iodine uptake patterns.

How It Works

  • Sodium Iodide (131I) is actively transported into thyroid follicular cells via the sodium‑iodide symporter. Once inside the gland, the radioactive iodine emits beta particles that destroy thyroid tissue while simultaneously emitting gamma photons that can be captured for imaging, allowing both diagnostic visualization and therapeutic ablation of hyperfunctioning or malignant thyroid cells.

Side Effects

Common Side Effects

  • Nausea: mild gastrointestinal upset after ingestion.
  • Metallic taste: transient alteration in taste perception.
  • Salivary gland swelling: mild sialadenitis causing discomfort.
  • Dry mouth: reduced salivary flow.

Serious or Rare Side Effects

  • Severe hypothyroidism: prolonged reduction in thyroid hormone requiring levothyroxine therapy.
  • Radiation thyroiditis: painful inflammation of the thyroid gland.
  • Bone marrow suppression: rare decrease in blood cell counts that may lead to anemia or infection.

Precautions & Warnings

Moniyot-131 should be used with caution and under professional supervision.

  • Pregnancy: avoid use unless benefits outweigh risks, as fetal thyroid may be affected.
  • Breastfeeding: discontinue nursing or stop medication, as iodine can be secreted in milk.
  • Concurrent antithyroid drugs: may reduce uptake, consider withholding before administration.
  • Renal impairment: adjust dose or monitor, as excretion is renal.
  • Thyroid function monitoring: assess hormone levels before and after treatment.
  • Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Moniyot-131 may interact with several medications and substances.

Major Interactions (Avoid)

  • Antithyroid medications (e.g., methimazole, propylthiouracil): block iodine uptake, reducing efficacy.
  • Lithium therapy: interferes with iodine transport, diminishing therapeutic effect.
  • High dietary iodine intake: competes with radioactive iodine, lowering glandular absorption.

Moderate Interactions (Monitor Closely)

  • Levothyroxine replacement: may require dose adjustment after ablation.
  • Beta‑blockers: may mask symptoms of thyroid storm, monitor clinical status.
  • Diuretics: can affect renal clearance of iodine, watch for accumulation.

Frequently Asked Questions

Moniyot-131 is a radioactive iodine preparation used primarily for thyroid imaging, treatment of hyperthyroidism, and ablation of residual thyroid tissue after thyroid cancer surgery. It helps clinicians assess gland function, reduce excess hormone production, and lower the risk of cancer recurrence.

Sodium Iodide (131I) is taken up by thyroid cells through the sodium‑iodide symporter. Inside the gland, it emits beta particles that destroy thyroid tissue and gamma photons that can be detected for imaging, providing both therapeutic and diagnostic capabilities.

The dose of Moniyot-131 is individualized and determined by the prescribing physician based on the specific indication, patient weight, thyroid function, and clinical goals. No standard dosing can be provided without a medical assessment.

Moniyot-131 is generally contraindicated in pregnancy because the radioactive iodine can affect fetal thyroid development. Breastfeeding should be discontinued or the medication avoided, as iodine can be secreted in breast milk and expose the infant to radiation.

To order Moniyot-131, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Moniyot-131 is a sodium iodide formulation of I‑131, similar to other I‑131 products used for thyroid imaging and therapy. Compared with non‑radioactive alternatives, it offers the unique ability to both visualize and treat thyroid tissue in a single agent, but it requires careful radiation safety handling.

Moniyot-131 should be stored below 25 °C in its original packaging, protected from moisture and light. Because it is a radioactive product, handling must follow local radiation safety regulations, and any unused material should be returned or disposed of according to authorized waste procedures.

Moniyot-131 is administered orally, typically as a single dose in capsule or liquid form. Patients are instructed to swallow the dose with water and may be advised to avoid certain foods or medications that could interfere with iodine uptake for a short period before and after dosing.

Serious risks include severe hypothyroidism requiring lifelong hormone replacement, radiation‑induced thyroiditis causing painful swelling, and, rarely, bone‑marrow suppression leading to blood‑cell abnormalities. Patients should be monitored for symptoms such as extreme fatigue, neck pain, or unexplained bruising.

Moniyot-131 should not be used in pregnant women, nursing mothers, patients with uncontrolled hyperthyroidism who have not been prepared appropriately, individuals with severe renal impairment without dose adjustment, and anyone who cannot comply with radiation safety guidelines.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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