Product image of Moniyot-131 Zur Therapie (Sodium Iodide (131i)) supplied by GNH India

Moniyot-131 Zur Therapie

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Moniyot-131 Zur Therapie (Sodium Iodide (131i))

Sodium Iodide (I-131), the active ingredient in Moniyot-131 Zur Therapie, is a radiopharmaceutical presented as an oral preparation for systemic use. It is employed in the selective ablation of thyroid tissue for patients with residual thyroid tissue after surgery, hyperthyroidism, or differentiated thyroid carcinoma.
GNH India supplies Moniyot-131 Zur Therapie as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Monrol Europe Srl

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Indications & Clinical Uses

Moniyot-131 Zur Therapie is a radioactive iodine agent used in thyroid‑related disease management. It targets thyroid tissue to achieve therapeutic ablation.

  • Ablation of residual thyroid tissue after thyroidectomy: eliminates remaining thyroid cells post‑surgery.
  • Treatment of hyperthyroidism (e.g., Graves' disease): reduces excess thyroid hormone production.
  • Management of differentiated thyroid carcinoma: destroys malignant thyroid cells and helps prevent disease recurrence.

How It Works

  • Sodium Iodide (I-131) is actively taken up by thyroid follicular cells via the sodium‑iodide symporter. Once inside the gland, the isotope emits beta particles that cause localized cellular DNA damage, leading to selective destruction of thyroid tissue, while accompanying gamma emissions allow imaging and dosimetry.

Side Effects

Adverse reactions may occur following oral administration of I-131.

Common Side Effects

  • Nausea or vomiting.
  • Dry mouth or altered taste sensation.
  • Transient sialadenitis (salivary gland inflammation).
  • Mild leukopenia or fatigue.

Serious or Rare Side Effects

  • Severe sialadenitis requiring medical intervention.
  • Bone marrow suppression leading to pancytopenia.
  • Pulmonary fibrosis or interstitial lung disease.
  • Allergic reactions including rash or anaphylaxis.
  • Secondary malignancies due to radiation exposure.

Precautions & Warnings

Use of Moniyot-131 Zur Therapie requires careful patient assessment and safety measures.

  • Pregnancy: avoid unless benefits outweigh potential fetal risks.
  • Breastfeeding: contraindicated; discontinue nursing prior to therapy.
  • Thyroid function: confirm diagnosis and baseline labs before administration.
  • Renal function: evaluate and adjust if significant impairment exists.
  • Radiation safety: implement shielding and limit exposure to staff and family.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

I-131 therapy can be affected by other medications that influence iodine metabolism or bone marrow function.

Major Interactions (Avoid)

  • Thyroid hormone replacement: may diminish therapeutic efficacy.
  • Antithyroid drugs (e.g., methimazole, propylthiouracil): interfere with iodine uptake.
  • Lithium: alters thyroid iodine handling and can reduce treatment response.

Moderate Interactions (Monitor Closely)

  • Potassium iodide: can block I-131 uptake if administered shortly before therapy.
  • Amiodarone: high iodine load may affect treatment outcomes.
  • Chemotherapeutic agents causing bone marrow suppression: increase risk of hematologic toxicity.

Frequently Asked Questions

Moniyot-131 Zur Therapie contains radioactive sodium iodide (I-131) and is used to ablate thyroid tissue. It is indicated for eliminating residual thyroid tissue after thyroidectomy, treating hyperthyroidism such as Graves' disease, and managing differentiated thyroid carcinoma by destroying malignant thyroid cells.

Sodium Iodide (I-131) is actively taken up by thyroid cells via the sodium‑iodide symporter. Inside the gland, the isotope emits beta radiation that damages cellular DNA, leading to selective destruction of thyroid tissue, while gamma emissions enable imaging and dose verification.

The appropriate dose of Moniyot-131 Zur Therapie is determined by the prescribing physician based on the patient’s clinical condition, thyroid uptake studies, and treatment goals. Dosage is individualized and not standardized across all patients.

The safety of Moniyot-131 Zur Therapie in pregnancy and breastfeeding is not established. It is generally avoided because radioactive iodine can cross the placenta and enter breast milk, potentially harming the fetus or infant. Consultation with a specialist is essential before use.

To order Moniyot-131 Zur Therapie, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Moniyot-131 Zur Therapie is a radioactive iodine option that offers targeted tissue ablation with a single oral dose, unlike antithyroid drugs that require prolonged oral therapy. Compared with external beam radiation, I-131 provides selective thyroid uptake, reducing exposure to surrounding tissues.

Moniyot-131 Zur Therapie should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct light. Follow local regulations for handling radioactive materials, including using appropriate shielding and disposal procedures.

The medication is administered orally as a single dose, usually in capsule or liquid form, under the supervision of a qualified nuclear medicine specialist. Patients may be instructed to drink plenty of fluids and follow radiation safety guidelines after ingestion.

Serious risks include severe sialadenitis, bone marrow suppression leading to pancytopenia, pulmonary fibrosis, allergic reactions, and the rare possibility of secondary malignancies due to radiation exposure. Patients should be monitored closely for these complications.

Moniyot-131 Zur Therapie is contraindicated in pregnant or breastfeeding women, patients with severe renal impairment, those with known hypersensitivity to iodine or radioactive iodine, and individuals unable to comply with radiation safety precautions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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