Product image of Monkasta (Montelukast) supplied by GNH India

Monkasta

Active Ingredient:
Montelukast
Origin:
EU

Monkasta (Montelukast)

Montelukast, the active ingredient in Monkasta, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It treats asthma, allergic rhinitis and exercise‑induced bronchoconstriction in adults and children.

GNH India supplies Monkasta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Monkasta (montelukast) acts on the leukotriene pathway to control chronic airway disorders.

  • Asthma: improves control of persistent asthma and reduces exacerbations.
  • Allergic rhinitis: relieves nasal congestion, sneezing and itching caused by seasonal or perennial allergens.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing that occurs during or after physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth muscle and inflammatory cells. By antagonising this receptor, it inhibits leukotriene‑mediated bronchoconstriction, mucus secretion, vascular permeability and eosinophilic inflammation, thereby improving airflow and reducing allergic symptoms.

Side Effects

Adverse reactions may range from mild to serious and should be monitored during therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Upper respiratory tract infection: nasopharyngitis or common cold symptoms.
  • Abdominal pain: discomfort or cramping in the stomach area.
  • Diarrhoea: loose stools occurring intermittently.
  • Cough: non‑productive cough episodes.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Neuropsychiatric events: agitation, depression or suicidal thoughts.
  • Angioedema: swelling of lips, tongue or face.
  • Hepatotoxicity: elevated liver enzymes indicating liver stress.
  • Anaphylaxis: severe, life‑threatening allergic reaction.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Pregnancy: discuss potential risks with a healthcare professional; data are limited.
  • Breastfeeding: evaluate benefits versus possible infant exposure.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Concomitant medications: review all current drugs for possible interactions.
  • Age restrictions: ensure appropriate dosing for pediatric patients as prescribed.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Montelukast may interact with other medicines; monitoring is advised.

Major Interactions (Avoid)

  • Phenobarbital: may reduce montelukast plasma concentrations.
  • Rifampin: strong enzyme inducer that can lower therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Antidepressants (e.g., fluoxetine): potential for neuropsychiatric side effects.
  • Warfarin: occasional reports of altered INR; monitor coagulation.
  • Beta‑agonists: additive bronchodilator effect may increase risk of tremor.
  • Antihistamines: combined use may increase sedation in sensitive individuals.

Frequently Asked Questions

Monkasta contains montelukast, which is prescribed for the long‑term management of persistent asthma, relief of seasonal or perennial allergic rhinitis, and prevention of exercise‑induced bronchoconstriction in both adults and children.

Montelukast blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes from causing airway narrowing, mucus production, and inflammation. This action helps keep the airways open and reduces allergic symptoms.

The appropriate dose of Monkasta is determined by the prescribing clinician based on the patient’s age, weight, and specific condition. Dosage instructions are provided on the prescription label and should be followed exactly.

Safety data for montelukast in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against possible risks before prescribing Monkasta to pregnant or nursing individuals.

To place an order, submit an enquiry on the Monkasta product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Monkasta (montelukast) belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients who prefer a once‑daily tablet or need additional control of allergic rhinitis alongside asthma.

Monkasta tablets should be stored at ambient temperature, below 25 °C, in their original container. Protect them from moisture, excessive heat and direct sunlight to maintain potency.

Monkasta is taken orally, usually once daily in the evening, with or without food, as directed by the prescribing healthcare professional.

Serious adverse events, though rare, can include neuropsychiatric reactions such as mood changes, depression or suicidal thoughts, as well as severe allergic responses like angioedema, anaphylaxis, and rare skin disorders such as Stevens‑Johnson syndrome.

Monkasta is contraindicated in individuals with known hypersensitivity to montelukast or any of the tablet’s excipients. Patients with a history of severe neuropsychiatric reactions should also avoid use unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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