Product image of Monocinque (Isosorbide 5 Mononitrate) supplied by GNH India

Monocinque

Active Ingredient:
Isosorbide 5 Mononitrate
Origin:
EU

Monocinque (Isosorbide 5 Mononitrate)

Isosorbide 5 Mononitrate, the active ingredient in Monocinque, is a nitrate vasodilator presented as an oral formulation for oral use. It is used for the prevention and treatment of chronic stable angina pectoris in adults.
GNH India supplies Monocinque as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Istituto Luso Farmaco D'italia S.P.A.

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Indications & Clinical Uses

Isosorbide 5 Mononitrate is indicated for conditions involving myocardial oxygen demand and supply imbalance.

  • Chronic stable angina: reduces the frequency of chest pain episodes during daily activities.
  • Exercise‑induced angina: improves exercise tolerance by decreasing cardiac workload.
  • Angina prophylaxis: helps prevent angina attacks during physical or emotional stress.

How It Works

  • Isosorbide 5 Mononitrate is metabolized to nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP causes relaxation of arterial and venous walls, producing vasodilation that lowers both preload and afterload, thereby reducing myocardial oxygen consumption and alleviating angina.

Side Effects

Isosorbide 5 Mononitrate may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate, often transient.
  • Flushing: warm sensation, especially after the first dose.
  • Dizziness or light‑headedness: related to blood pressure reduction.
  • Nausea or abdominal discomfort.
  • Palpitations: sensation of irregular heartbeat.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Syncope: fainting episodes.
  • Methemoglobinemia: rare discoloration of blood.
  • Allergic reactions: rash, itching, or swelling.
  • Chest pain worsening: paradoxical increase in angina.

Precautions & Warnings

Before prescribing Isosorbide 5 Mononitrate, consider the following safety measures.

  • Cardiovascular assessment: evaluate blood pressure and heart rate baseline.
  • Concomitant nitrates: avoid combined use to prevent severe hypotension.
  • Phosphodiesterase‑5 inhibitors: contraindicated due to risk of profound vasodilation.
  • Hepatic or renal impairment: adjust monitoring as clearance may be affected.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Isosorbide 5 Mononitrate can interact with several drug classes.

Major Interactions (Avoid)

  • Other nitrates (e.g., nitroglycerin): may cause dangerous drops in blood pressure.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of severe hypotension.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (e.g., ACE inhibitors, beta‑blockers): additive blood pressure‑lowering effect.
  • Diuretics: may enhance orthostatic hypotension.
  • Alcohol: can increase vasodilatory response and dizziness.

Frequently Asked Questions

Monocinque contains Isosorbide 5 Mononitrate and is used to prevent and treat chronic stable angina pectoris. It helps reduce the frequency and severity of chest pain episodes by improving blood flow to the heart muscle.

The active ingredient releases nitric oxide, which activates guanylate cyclase in vascular smooth muscle. This raises cyclic GMP levels, causing relaxation of arteries and veins, lowering cardiac preload and afterload, and decreasing myocardial oxygen demand.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Isosorbide 5 Mononitrate in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Monocinque belongs to the nitrate class, which provides rapid vasodilation. Compared with beta‑blockers or calcium‑channel blockers, nitrates primarily reduce preload and afterload, offering a complementary mechanism. Choice of therapy depends on individual patient profile and physician judgment.

Store Monocinque at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight to maintain stability.

Monocinque is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the prescriber’s directions regarding timing and any specific administration instructions.

The most serious risks include severe hypotension, syncope, and rare cases of methemoglobinemia. Patients should seek immediate medical attention if they experience fainting, a sudden drop in blood pressure, or signs of an allergic reaction.

Monocinque should be avoided in patients who are concurrently using other nitrates, phosphodiesterase‑5 inhibitors, or who have known hypersensitivity to Isosorbide 5 Mononitrate. Clinicians should also exercise caution in patients with severe hypotension or recent myocardial infarction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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