Product image of Monofloxofta (Ofloxacin) supplied by GNH India

Monofloxofta

Active Ingredient:
Ofloxacin
Origin:
EU

Monofloxofta (Ofloxacin)

Ofloxacin, the active ingredient in Monofloxofta, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. It treats bacterial eye infections such as conjunctivitis and keratitis in both adults and children.

GNH India supplies Monofloxofta as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fidia Farmaceutici S.P.A

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Indications & Clinical Uses

Monofloxofta is indicated for bacterial eye infections, targeting the ocular surface and corneal tissues.

  • Bacterial conjunctivitis: reduces bacterial load and accelerates resolution of redness, discharge, and irritation.
  • Bacterial keratitis: eradicates causative organisms to promote corneal healing and preserve vision.
  • Other bacterial eye infections: treats conditions such as blepharitis and corneal ulceration caused by susceptible bacteria.

How It Works

  • Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By binding to these enzymes, the drug prevents bacterial cell division and leads to bacterial death. This bactericidal activity is effective against a broad spectrum of Gram‑negative and Gram‑positive ocular pathogens, making it suitable for topical ophthalmic therapy.

Side Effects

Ophthalmic administration of Ofloxacin may be associated with local and systemic adverse reactions.

Common Side Effects

  • Eye irritation: mild burning or stinging upon instillation.
  • Redness: transient conjunctival hyperemia.
  • Tearing: increased lacrimation.
  • Foreign body sensation: feeling of grit in the eye.
  • Blurred vision: temporary visual disturbance after dosing.
  • Photophobia: sensitivity to light.

Serious or Rare Side Effects

  • Allergic reaction: swelling, rash, or hives around the eye.
  • Corneal ulceration: worsening of corneal lesions.
  • Severe eye pain: intense discomfort indicating possible toxicity.
  • Vision loss: rare but potentially permanent visual impairment.
  • Stevens‑Johnson syndrome: extremely rare systemic skin reaction.

Precautions & Warnings

Before prescribing Monofloxofta, clinicians should consider the following precautions.

  • Assess allergy: confirm no hypersensitivity to fluoroquinolones or other ophthalmic agents.
  • Avoid use in patients with known hypersensitivity to Ofloxacin or related compounds.
  • Monitor for signs of corneal toxicity: discontinue if ulceration or worsening occurs.
  • Use with caution in contact lens wearers: advise removal of lenses during treatment.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Ofloxacin eye drops can interact with other medications; awareness of these interactions helps minimize risk.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: concurrent use may increase risk of tendon or cartilage toxicity.
  • Corticosteroid eye drops: may mask infection signs and delay healing.
  • Non‑steroidal anti‑inflammatory eye drops: potential for delayed corneal epithelial repair.

Moderate Interactions (Monitor Closely)

  • Anticholinergic ophthalmic agents: may reduce tear production and affect drug distribution.
  • Herbal supplements containing quinine: possible additive QT‑interval prolongation.
  • Vitamin A derivatives (retinoids): may influence corneal epithelial turnover.

Frequently Asked Questions

Monofloxofta is an ophthalmic preparation containing Ofloxacin that is used to treat bacterial infections of the eye. It is commonly prescribed for conditions such as bacterial conjunctivitis, bacterial keratitis, and other susceptible bacterial eye infections, helping to reduce symptoms and eradicate the causative microorganisms.

Ofloxacin belongs to the fluoroquinolone class and works by inhibiting two essential bacterial enzymes, DNA gyrase and topoisomerase IV. These enzymes are required for DNA replication and transcription. By blocking their activity, Ofloxacin prevents bacterial cell division, leading to bacterial death and resolution of the infection.

The dosing regimen for Monofloxofta is determined by the prescribing clinician based on the specific infection, severity, and patient factors. The prescriber will specify the number of drops, frequency, and duration of therapy on the prescription label.

Safety data for topical Ofloxacin during pregnancy and lactation are limited. The decision to use Monofloxofta in pregnant or nursing women should be made after a careful risk‑benefit assessment by the healthcare professional, considering the severity of the eye infection and available alternatives.

To order Monofloxofta, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Monofloxofta (Ofloxacin) offers broad‑spectrum activity against many Gram‑negative and Gram‑positive ocular pathogens, similar to other fluoroquinolone eye drops such as ciprofloxacin. Compared with older agents like chloramphenicol, Ofloxacin generally provides faster bacterial eradication and a lower risk of resistance, though choice depends on local susceptibility patterns and patient tolerance.

Monofloxofta should be stored at room temperature, below 25 °C, in its original container. Protect the product from direct light and moisture. Do not freeze the solution, and keep the vial tightly closed when not in use to maintain sterility.

Monofloxofta is applied as eye drops. The patient should wash their hands, tilt the head back, pull down the lower eyelid to form a pocket, and instill the prescribed number of drops into the conjunctival sac. The eye should be closed gently for a few seconds to allow distribution, and contact lenses should be removed during treatment.

Serious risks, although rare, include severe allergic reactions such as swelling or rash around the eye, corneal ulceration or worsening of existing corneal lesions, significant eye pain, and in extremely rare cases, systemic hypersensitivity reactions like Stevens‑Johnson syndrome. Any of these symptoms require immediate discontinuation and medical evaluation.

Monofloxofta should not be used by individuals with a known hypersensitivity to Ofloxacin, other fluoroquinolones, or any component of the ophthalmic formulation. Patients with a history of severe ocular surface disease or those who have experienced serious adverse reactions to fluoroquinolone eye drops should avoid its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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