Product image of Monofree (Oxybuprocaine Hydrochloride) supplied by GNH India

Monofree

Active Ingredient:
Oxybuprocaine Hydrochloride
Origin:
EU

Monofree (Oxybuprocaine Hydrochloride)

Oxybuprocaine Hydrochloride, the active ingredient in Monofree, is a local anesthetic presented as a sterile ophthalmic solution for ocular use. It provides rapid, reversible numbing of the corneal and conjunctival surface for diagnostic examinations and minor surgical procedures in adult patients and is commonly employed in ophthalmology clinics across the European market.

GNH India supplies Monofree as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Laboratoires Thea

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Indications & Clinical Uses

Oxybuprocaine Hydrochloride is a topical ocular anesthetic used to temporarily block sensation in the eye surface.

  • Slit‑lamp examination: provides rapid numbness to facilitate comfortable corneal evaluation.
  • Foreign body removal: enables painless extraction of superficial ocular debris.
  • Laser ophthalmic procedures: offers short‑acting anesthesia for laser photocoagulation or refractive surgery.

How It Works

  • Oxybuprocaine Hydrochloride acts by reversibly binding to voltage‑gated sodium channels on peripheral nerve membranes in the cornea and conjunctiva. This blockade prevents sodium influx required for depolarisation, inhibiting nerve impulse propagation. The result is a rapid, localized loss of sensation without affecting systemic nerve function, allowing brief ocular procedures to be performed with minimal discomfort.

Side Effects

Adverse reactions to ocular administration of Oxybuprocaine Hydrochloride are generally limited to the treated eye.

Common Side Effects

  • Burning or stinging sensation on instillation.
  • Transient conjunctival redness.
  • Increased tearing.
  • Temporary blurred vision.

Serious or Rare Side Effects

  • Corneal epithelial defect or ulceration.
  • Severe allergic reaction (anaphylaxis).
  • Endophthalmitis.

Precautions & Warnings

When using Monofree, clinicians should observe several safety measures to minimise risk.

  • Allergy assessment: verify no known hypersensitivity to oxybuprocaine or related anesthetics.
  • Limit duration: avoid repeated applications beyond the recommended clinical interval.
  • Corneal health: do not use on compromised corneal epithelium or active infection.
  • Concomitant drugs: exercise caution when combined with other topical ocular anesthetics.
  • Systemic conditions: monitor patients with cardiac conduction disorders, although systemic absorption is minimal.
  • Store at controlled room temperature: keep below 25 °C, in the original container, protected from light and moisture.

Avoid Interactions

Oxybuprocaine Hydrochloride may interact with other ophthalmic agents; awareness of potential interactions helps maintain safety.

Major Interactions (Avoid)

  • Other topical ocular anesthetics: additive neurotoxicity may increase corneal damage.
  • Anticholinergic eye drops: may exacerbate dry eye and delay healing.

Moderate Interactions (Monitor Closely)

  • Beta‑blocker ophthalmic solutions: monitor for potential additive effects on intra‑ocular pressure.
  • Steroid eye drops: assess for delayed epithelial recovery.
  • Systemic sodium channel blockers (e.g., antiarrhythmics): observe for any unexpected systemic effects, although unlikely.

Frequently Asked Questions

Monofree contains Oxybuprocaine Hydrochloride, a local anesthetic applied as eye drops to provide short‑term numbness of the cornea and conjunctiva. It is used during diagnostic eye examinations, removal of superficial foreign bodies, and brief laser or surgical procedures on the eye.

The compound reversibly blocks voltage‑gated sodium channels on peripheral nerves in the ocular surface. By preventing sodium influx, it stops nerve depolarisation and impulse transmission, resulting in a rapid, localized loss of sensation without systemic nerve effects.

The dosage and frequency of Monofree are determined by the prescribing clinician based on the specific procedure and patient factors. The prescriber will specify the number of drops and the interval between applications.

Safety data for Oxybuprocaine Hydrochloride in pregnancy or lactation are limited. Clinicians should weigh potential benefits against unknown risks and consider alternative options when treating pregnant or nursing patients.

To place an order, submit an enquiry on the Monofree product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Monofree (Oxybuprocaine) offers rapid onset and short duration of action, similar to other topical anesthetics such as proparacaine or tetracaine. Choice among them depends on clinician preference, specific procedural needs, and individual patient tolerance.

Monofree should be stored at controlled room temperature, below 25 °C. Keep the vial in its original packaging, protect it from light and moisture, and do not freeze. Follow any additional instructions on the label.

Monofree is applied as an ophthalmic solution. The prescriber directs the patient or clinician to instil the specified number of drops onto the conjunctival sac, typically shortly before the intended ocular procedure.

Serious, though rare, risks include corneal epithelial defects or ulceration, severe allergic reactions such as anaphylaxis, and intra‑ocular infections like endophthalmitis. Immediate medical attention is required if any of these events occur.

Monofree should be avoided in individuals with known hypersensitivity to oxybuprocaine or any component of the formulation, and in patients with active corneal infections or compromised epithelial integrity unless specifically directed by a qualified eye‑care professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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