Product image of Monoketo (Ketotifen Hydrogen Fumarate) supplied by GNH India

Monoketo

Active Ingredient:
Ketotifen Hydrogen Fumarate
Origin:
EU

Monoketo (Ketotifen Hydrogen Fumarate)

Ketotifen, the active ingredient in Monoketo, is an antihistamine / mast cell stabilizer presented as an ophthalmic solution for ocular use. It is used to relieve eye itching, redness and swelling caused by allergic conjunctivitis and seasonal allergic eye disease in adults and children.

GNH India supplies Monoketo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Horus Pharma

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Indications & Clinical Uses

Monoketo, an ophthalmic antihistamine and mast cell stabilizer, is indicated for allergic conditions of the eye.

  • Allergic conjunctivitis: reduces ocular itching, redness and tearing associated with allergic inflammation.
  • Seasonal allergic eye disease: alleviates symptoms triggered by pollen or seasonal allergens.
  • Itching of the eyes: provides rapid relief of eye itch caused by histamine release.

How It Works

  • Ketotifen blocks H1 histamine receptors on ocular tissues and stabilizes mast cells, preventing the release of histamine and other inflammatory mediators. By inhibiting these pathways, it reduces vascular permeability, edema and sensory nerve activation that cause itching, redness and swelling in the conjunctiva.

Side Effects

Ketotifen eye drops are generally well tolerated, but ocular preparations can cause local reactions.

Common Side Effects

  • Stinging or burning sensation upon instillation
  • Transient blurred vision
  • Mild eye redness
  • Temporary itching or irritation
  • Dry eye sensation
  • Mild headache

Serious or Rare Side Effects

  • Allergic reaction (e.g., swelling of eyelids, rash)
  • Corneal ulcer or epithelial defect
  • Severe eye pain or photophobia
  • Vision loss or significant visual disturbance
  • Persistent intraocular inflammation

Precautions & Warnings

When using Monoketo, consider the following safety measures.

  • Allergy assessment: avoid if known hypersensitivity to ketotifen or any excipients.
  • Contact lens use: discontinue lenses before and after instillation unless advised by an eye‑care professional.
  • Persistent symptoms: seek medical advice if irritation continues beyond 7 days.
  • Contamination risk: keep the dropper tip clean and avoid touching it to any surface.
  • Storage: Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketotifen eye drops may interact with other medications affecting ocular or systemic histamine pathways.

Major Interactions (Avoid)

  • Systemic antihistamines or mast cell stabilizers: may increase cumulative antihistaminic effect.
  • MAO inhibitors: potential for enhanced central antihistamine activity.

Moderate Interactions (Monitor Closely)

  • Topical ocular corticosteroids: monitor intra‑ocular pressure when used together.
  • Alcohol or sedatives: may exacerbate ocular dryness.
  • Other ophthalmic solutions (e.g., mydriatics): stagger administration to prevent dilution or reduced efficacy.

Frequently Asked Questions

Monoketo is an ophthalmic preparation containing ketotifen, used to relieve symptoms of allergic conjunctivitis, seasonal allergic eye disease, and eye itching. It works locally in the eye to reduce redness, swelling, and discomfort caused by allergic reactions.

Ketotifen blocks H1 histamine receptors on ocular cells and stabilizes mast cells, preventing the release of histamine and other inflammatory mediators. This dual action reduces vascular leakage, edema, and nerve irritation that produce itching, redness, and tearing.

The dosing regimen for Monoketo is determined by the prescribing eye‑care professional. Typically, one or two drops are instilled in the affected eye(s) as directed, but the exact frequency and duration should follow the prescriber’s instructions.

Safety data for ketotifen eye drops in pregnancy and lactation are limited. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Monoketo.

To order Monoketo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.

Monoketo combines antihistamine and mast‑cell‑stabilizing actions in a single ophthalmic formulation, offering both rapid symptom relief and longer‑term control. Alternative treatments may include separate antihistamine drops, mast‑cell stabilizers, or non‑steroidal anti‑inflammatory eye drops, each with distinct efficacy and safety profiles.

Monoketo should be stored at room temperature, away from direct sunlight and moisture. Keep the bottle tightly closed in its original packaging, and avoid freezing. Discard any solution that appears discolored or contains particles.

Monoketo is applied topically to the eye. After washing hands, tilt the head back, pull down the lower eyelid, and place the prescribed number of drops into the conjunctival sac. Close the eye gently and avoid blinking excessively for a few seconds to allow absorption.

Serious but rare risks include allergic reactions such as eyelid swelling, rash, or severe eye irritation, as well as corneal ulceration or significant visual disturbances. If any of these occur, discontinue use immediately and seek urgent medical attention.

Monoketo should not be used by individuals with a known hypersensitivity to ketotifen or any component of the formulation. It is also contraindicated in patients who have active ocular infections or severe ocular surface disease unless advised by an eye‑care specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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