Mononit 100 Retard (Isosorbide Mononitrate)

Isosorbide mononitrate is converted in the body to nitric oxide, a potent vasodilator. Nitric oxide activates guanylate cyclase, increasing cyclic GMP levels, which relaxes vascular smooth muscle, lowers preload and afterload, and enhances myocardial oxygen supply.

The specific dose of Mononit 100 Retard is determined by the prescribing clinician based on the individual’s condition, response, and tolerability. Typical regimens start with a low dose that may be titrated upward, but exact dosing must follow the prescriber’s order.

The pregnancy category for isosorbide mononitrate is not definitively established. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider, as the drug may pass into breast milk.

To order Mononit 100 Retard, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mononit 100 Retard belongs to the organic nitrate class, offering once‑daily extended‑release dosing, which can improve adherence compared with short‑acting nitrates like nitroglycerin. Unlike beta‑blockers, it primarily reduces cardiac preload and afterload without affecting heart rate, making it a useful adjunct or alternative in patients who cannot tolerate beta‑blockers.

Store Mononit 100 Retard at ambient temperature below 25 °C, in the original blister pack, protected from moisture and direct sunlight. Do not store in a bathroom or near heat sources. Keep out of reach of children.

Mononit 100 Retard is taken orally as an extended‑release tablet. Swallow the tablet whole with a glass of water; do not crush, chew, or split it, as this can release the entire dose at once and increase the risk of side effects.

Serious risks include severe hypotension, syncope (fainting), and rare allergic reactions such as rash, swelling or anaphylaxis. Patients should seek immediate medical attention if they experience sudden dizziness, fainting, chest pain, or signs of an allergic response.

Mononit 100 Retard should be avoided in patients with known hypersensitivity to isosorbide mononitrate or other organic nitrates, those with severe anemia, uncontrolled hypotension, or who are concurrently using phosphodiesterase‑5 inhibitors. It is also contraindicated in patients with recent head trauma or increased intracranial pressure.