Product image of Monoox (Ofloxacin) supplied by GNH India

Monoox

Active Ingredient:
Ofloxacin
Origin:
EU

Monoox (Ofloxacin)

Ofloxacin, the active ingredient in Monoox, is a fluoroquinolone presented as an ophthalmic solution for ocular use. It treats bacterial infections of the eye such as conjunctivitis, keratitis and corneal ulcers in patients requiring prescription therapy.

GNH India supplies Monoox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Horus Pharma

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Indications & Clinical Uses

Ofloxacin is a fluoroquinolone antibacterial used for ocular infections affecting the conjunctiva and cornea.

  • Bacterial conjunctivitis: reduces bacterial load and resolves redness and discharge.
  • Keratitis: eradicates causative bacteria, promoting corneal healing.
  • Corneal ulcer: prevents progression of infection and supports tissue repair.

How It Works

  • Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By blocking these targets, it prevents bacterial cell division and leads to bacterial cell death, providing a bactericidal effect against susceptible ocular pathogens.

Side Effects

Ophthalmic administration of Ofloxacin may be associated with local and systemic adverse reactions.

Common Side Effects

  • Eye irritation: mild burning or stinging upon instillation.
  • Redness: transient conjunctival hyperemia.
  • Tearing: increased lacrimation.
  • Foreign body sensation: feeling of grit in the eye.
  • Blurred vision: temporary visual disturbance.
  • Mild headache: occasional frontal discomfort.

Serious or Rare Side Effects

  • Allergic reaction: swelling, itching, or rash around the eye.
  • Severe ocular inflammation: marked pain, swelling, or ulceration.
  • Vision loss: sudden decrease in visual acuity.
  • Stevens‑Johnson syndrome: rare mucocutaneous eruption.
  • Systemic hypersensitivity: anaphylaxis in extremely rare cases.

Precautions & Warnings

When prescribing Ofloxacin eye drops, clinicians should consider several safety measures.

  • Allergy assessment: confirm no known hypersensitivity to fluoroquinolones.
  • Prescription use only: administer exactly as directed by a qualified professional.
  • Infection monitoring: observe for worsening signs or lack of improvement.
  • Contact lens avoidance: remove lenses during treatment to prevent contamination.
  • Storage at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Ofloxacin ophthalmic solution can interact with systemic and topical agents.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: concurrent use may increase risk of tendon toxicity.
  • Cimetidine or antacids containing aluminum/magnesium: may reduce systemic absorption if used orally.

Moderate Interactions (Monitor Closely)

  • Corticosteroid eye drops: may mask signs of infection.
  • NSAID eye preparations: monitor for additive irritation.
  • Warfarin: observe coagulation parameters due to potential enhanced anticoagulant effect.

Frequently Asked Questions

Monoox contains Ofloxacin and is indicated for bacterial eye infections such as bacterial conjunctivitis, keratitis and corneal ulcers. It is prescribed when a clinician determines that a fluoroquinolone antibiotic is appropriate for the ocular pathogen.

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By blocking these enzymes, the drug prevents bacterial cell division, leading to bacterial death and clearance of the infection in the ocular tissues.

The dosing regimen for Monoox is determined by the prescribing ophthalmologist based on the severity of the infection, patient age and response to therapy. The prescriber will specify the number of drops, frequency and duration of treatment.

Safety data for Ofloxacin in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Clinicians should weigh potential benefits against risks and consider alternative treatments when treating pregnant or nursing patients.

To request Monoox, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Monoox (Ofloxacin) is a fluoroquinolone, offering broad‑spectrum coverage against Gram‑negative and some Gram‑positive ocular pathogens. Compared with older agents such as chloramphenicol, Ofloxacin generally provides higher potency and a lower risk of resistance, though choice depends on local susceptibility patterns and patient factors.

Monoox should be stored at room temperature, below 25 °C, in its original container. Protect the product from direct sunlight, moisture and extreme temperatures to maintain stability and potency throughout its shelf life.

Monoox is applied as an eye drop. The prescriber will instruct the patient on the number of drops per eye, the frequency (e.g., one drop every 2–4 hours), and the total duration of therapy, ensuring proper technique to avoid contamination.

Serious risks, though rare, include severe allergic reactions such as swelling, rash or anaphylaxis, Stevens‑Johnson syndrome, and significant ocular inflammation that can lead to vision loss. Patients should seek immediate medical attention if they experience these symptoms.

Monoox should not be used by individuals with a known hypersensitivity to Ofloxacin, other fluoroquinolones, or any component of the formulation. It is also contraindicated in patients with a history of tendon disorders related to fluoroquinolone use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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