Product image of Monoprost (Latanoprost) supplied by GNH India

Monoprost

Active Ingredient:
Latanoprost
Origin:
EU

Monoprost (Latanoprost)

Latanoprost, the active ingredient in Monoprost, is a prostaglandin analog presented as an ophthalmic solution for ocular use. It treats open‑angle glaucoma and ocular hypertension by lowering intra‑ocular pressure, and is administered as a single drop in the affected eye(s) once daily for long‑term pressure control.

GNH India supplies Monoprost as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Thea

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Indications & Clinical Uses

Latanoprost, a prostaglandin analog, is used to manage conditions characterized by elevated intra‑ocular pressure.

  • Open‑angle glaucoma: reduces intra‑ocular pressure to prevent optic nerve damage.
  • Ocular hypertension: lowers eye pressure in patients at risk of developing glaucoma.
  • Pseudoexfoliative glaucoma: provides IOP reduction similar to primary open‑angle glaucoma.

How It Works

  • Latanoprost binds to prostaglandin F (FP) receptors in the ciliary muscle, promoting remodeling of the extracellular matrix and increasing uveoscleral outflow of aqueous humor. This enhanced outflow lowers intra‑ocular pressure, helping to protect the optic nerve from pressure‑related damage.

Side Effects

Latanoprost may cause ocular and systemic reactions. Patients should be aware of both common and rare events.

Common Side Effects

  • Eye redness: mild conjunctival hyperemia.
  • Increased eyelash growth: longer, thicker lashes.
  • Iris darkening: gradual brownish pigmentation.
  • Eye irritation: burning or stinging sensation.
  • Blurred vision: transient visual disturbance.
  • Foreign body sensation: feeling of grit in the eye.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, rash, or difficulty breathing.
  • Uveitis: inflammation of the uveal tract.
  • Macular edema: swelling of the central retina.
  • Paradoxical IOP increase: unexpected rise in pressure.
  • Corneal edema: swelling of the cornea affecting clarity.

Precautions & Warnings

Before using Monoprost, consider the following safety measures.

  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Breastfeeding: unknown excretion; exercise caution.
  • Contraindications: avoid in eyes with active infection or inflammation.
  • Monitor IOP: assess pressure response after 4–6 weeks of therapy.
  • Single‑dose vials: discard any remaining solution to prevent contamination.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Latanoprost may interact with other ocular or systemic agents.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory eye drops: may diminish IOP‑lowering effect.
  • Concurrent prostaglandin analogs: risk of additive ocular side effects.
  • Systemic carbonic anhydrase inhibitors: potential excessive IOP reduction; monitor closely.

Moderate Interactions (Monitor Closely)

  • Beta‑blocker eye drops: additive pressure‑lowering effect.
  • Alpha‑adrenergic agonist eye drops: may increase ocular irritation.
  • Systemic corticosteroids: possible reduction in therapeutic response.

Frequently Asked Questions

Monoprost contains latanoprost, a prostaglandin analog indicated for the treatment of open‑angle glaucoma and ocular hypertension. It works by lowering intra‑ocular pressure, helping to protect the optic nerve and prevent vision loss in patients with these conditions.

Latanoprost binds to FP receptors in the ciliary body, remodeling extracellular matrix and enhancing uveoscleral outflow of aqueous humor. This increased outflow reduces intra‑ocular pressure, which is the primary therapeutic goal in glaucoma and ocular hypertension.

The prescribed dose of Monoprost is determined by the treating ophthalmologist. Typically, one drop is instilled in the affected eye(s) once daily in the evening, but the exact regimen should follow the prescriber’s instructions.

Safety data for latanoprost in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the prescriber should evaluate each case individually.

To place an order, submit an enquiry on the Monoprost product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Monoprost is a prostaglandin analog, generally offering once‑daily dosing and a favorable IOP‑lowering profile compared with beta‑blocker or carbonic anhydrase inhibitor drops. Its side‑effect profile includes characteristic iris darkening and eyelash growth, which differ from the systemic effects sometimes seen with other classes.

Monoprost should be stored at room temperature, below 25 °C, in its original packaging. Keep the bottle away from direct sunlight and moisture, and discard any solution that appears discolored or contaminated.

Monoprost is administered as an ophthalmic solution. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place a single drop into the conjunctival sac of the affected eye(s). Close the eye gently for a few seconds and avoid blinking excessively.

Serious but rare risks include severe allergic reactions, uveitis, macular edema, paradoxical increase in intra‑ocular pressure, and corneal edema. Patients should seek immediate medical attention if they experience sudden vision changes, eye pain, or signs of an allergic response.

Monoprost is contraindicated in patients with active ocular infection or inflammation, and it should be used with caution in individuals with a history of hypersensitivity to latanoprost or any component of the formulation. Pregnant or nursing women should only use it if clearly needed and prescribed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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