Product image of Monoprost (Latanoprost) supplied by GNH India

Monoprost

Active Ingredient:
Latanoprost
Origin:
EU

Monoprost (Latanoprost)

Latanoprost, the active ingredient in Monoprost, is a prostaglandin analog presented as sterile ophthalmic eye drops for ocular administration. It works by increasing uveoscleral outflow of aqueous humor, thereby reducing intra‑ocular pressure. The medication is indicated for the management of primary open‑angle glaucoma and ocular hypertension in adult patients.

GNH India supplies Monoprost as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across all markets with reliable logistics and documentation support for global procurement.

Manufacturer / TM Owner

Laboratoires Thea

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Indications & Clinical Uses

Latanoprost is a prostaglandin analog used to lower intra‑ocular pressure in glaucoma‑related conditions.

  • Primary open‑angle glaucoma: reduces intra‑ocular pressure and helps slow progression of visual field loss.
  • Ocular hypertension: lowers pressure to prevent conversion to glaucoma.
  • Secondary open‑angle glaucoma: may be used as adjunct therapy to control intra‑ocular pressure.

How It Works

  • Latanoprost binds to prostaglandin F (FP) receptors in the ciliary muscle, activating a signaling cascade that remodels extracellular matrix and enhances uveoscleral outflow of aqueous humor. The increased outflow reduces intra‑ocular pressure, providing therapeutic benefit in glaucoma and ocular hypertension.

Side Effects

Adverse reactions may occur with ocular prostaglandin therapy.

Common Side Effects

  • Eye redness: mild conjunctival hyperemia.
  • Increased eyelash growth: longer, thicker lashes.
  • Iris darkening: gradual brownish pigmentation.
  • Eye irritation: burning or stinging sensation.
  • Blurred vision: transient visual disturbance.
  • Foreign body sensation: feeling of grit in the eye.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, rash, or anaphylaxis.
  • Uveitis: inflammation of the uveal tract.
  • Macular edema: swelling of the central retina.
  • Persistent ocular inflammation: prolonged redness or pain.
  • Vision loss: sudden decrease in visual acuity.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Monitor intra‑ocular pressure: ensure target pressure is achieved.
  • Assess for ocular infection: avoid use if active infection is present.
  • Caution in patients with a history of uveitis: may exacerbate inflammation.
  • Avoid contact lens wear during treatment: lenses can absorb the drug.
  • Evaluate systemic prostaglandin sensitivity: discontinue if systemic reactions occur.
  • Store at room temperature: keep bottle tightly closed, protect from light and freezing.

Avoid Interactions

Latanoprost may interact with other ocular or systemic agents.

Major Interactions (Avoid)

  • Other prostaglandin analog eye drops: additive pressure‑lowering effect may cause hypotony.
  • Systemic carbonic anhydrase inhibitors (e.g., acetazolamide): combined use can excessively lower intra‑ocular pressure.
  • Ocular surgery: increased risk of wound healing complications.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory eye drops: may increase ocular irritation.
  • Anticholinergic agents: potential for reduced efficacy of pressure control.
  • Beta‑blocker eye drops: monitor for additive hypotensive effect.

Frequently Asked Questions

Monoprost contains the active ingredient latanoprost and is prescribed to lower intra‑ocular pressure in adults with primary open‑angle glaucoma or ocular hypertension, helping to prevent optic nerve damage and preserve visual function.

Latanoprost binds to prostaglandin F (FP) receptors in the eye, triggering remodeling of the extracellular matrix in the ciliary body. This enhances uveoscleral outflow of aqueous humor, which reduces intra‑ocular pressure and mitigates glaucoma progression.

The dosing regimen is determined by the prescribing clinician. Typically, a single drop is instilled in the affected eye(s) once daily, but the exact dose and timing should follow the prescriber’s instructions.

Safety data for latanoprost in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To request Monoprost, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with beta‑blocker eye drops such as timolol, latanoprost generally offers once‑daily dosing and a different side‑effect profile, including cosmetic changes like iris darkening. Both classes effectively lower pressure, but individual response and tolerance guide the choice of therapy.

Monoprost should be stored at room temperature, below 25 °C, in the original container. Keep the bottle tightly closed, protect it from light, and avoid freezing. Do not refrigerate unless specifically instructed by the manufacturer.

Instill one drop of Monoprost into the affected eye(s) once daily, preferably in the evening. Wash hands before use, avoid touching the tip of the bottle to the eye or any surface, and close the bottle immediately after administration.

Serious adverse events, though rare, include severe allergic reactions, uveitis, macular edema, and sudden vision loss. Patients should seek immediate medical attention if they experience eye pain, significant redness, visual disturbances, or systemic allergic symptoms.

Monoprost is contraindicated in individuals with known hypersensitivity to latanoprost or any excipients, and in patients with active intra‑ocular inflammation or infection. Caution is also advised for those with a history of severe ocular inflammation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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