Product image of Monosan (Isosorbide Mononitrate) supplied by GNH India

Monosan

Active Ingredient:
Isosorbide Mononitrate
Origin:
EU

Monosan (Isosorbide Mononitrate)

Isosorbide Mononitrate, the active ingredient in Monosan, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed to prevent angina pectoris and to manage chronic stable angina in adult patients.
GNH India supplies Monosan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pro.Med.Cs Praha A.S.

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Indications & Clinical Uses

Monosan belongs to the nitrate vasodilator class and is used in the management of coronary artery disease‑related chest pain.

  • Angina pectoris (prevention): reduces the frequency of anginal episodes.
  • Chronic stable angina (management): improves exercise tolerance and decreases myocardial oxygen demand.
  • Ischemic heart disease (symptom control): alleviates chest discomfort associated with reduced coronary blood flow.

How It Works

  • Isosorbide mononitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of arterial and venous vessels, producing vasodilation, lowering preload and afterload, and consequently reducing myocardial oxygen consumption.

Side Effects

Adverse reactions may occur with any nitrate therapy.

Common Side Effects

  • Headache: mild to moderate throbbing pain, often transient.
  • Dizziness or light‑headedness: related to blood pressure reduction.
  • Flushing: warm sensation with reddening of the skin.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Syncope: fainting episodes due to inadequate cerebral perfusion.
  • Allergic reaction: rash, itching, or swelling indicating hypersensitivity.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Blood pressure monitoring: check baseline and periodic readings.
  • Avoid abrupt discontinuation: taper to prevent rebound angina.
  • Concomitant nitrate use: do not combine with other nitrate products.
  • Hepatic impairment: use with caution in patients with liver dysfunction.
  • Storage at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Isosorbide mononitrate may interact with several drug classes.

Major Interactions (Avoid)

  • Sildenafil and other PDE5 inhibitors: risk of severe hypotension.
  • Other organic nitrates (e.g., nitroglycerin): additive vasodilatory effect.
  • Nitroglycerin patches or sprays: may cause profound blood pressure fall.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, ARBs, beta‑blockers): additive blood pressure lowering.
  • Diuretics: potential for volume depletion and dizziness.
  • Alcohol: may enhance hypotensive response.

Frequently Asked Questions

Monosan contains isosorbide mononitrate, which is prescribed to prevent episodes of angina pectoris and to manage chronic stable angina by improving blood flow to the heart muscle.

The drug releases nitric oxide in the vascular wall, activating guanylate cyclase and increasing cyclic GMP levels. This cascade relaxes smooth muscle, dilates vessels, and lowers the heart’s oxygen demand.

The appropriate dose of Monosan is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for isosorbide mononitrate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and under medical supervision.

To place an order, submit an enquiry on the Monosan product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Monosan belongs to the nitrate class, offering long‑acting vasodilation. Compared with short‑acting nitrates, it provides more stable plasma levels and fewer dosing fluctuations, but it shares similar contraindications and side‑effect profiles with other nitrates.

Store Monosan at room temperature, below 25 °C, in the original packaging. Protect the tablets from moisture, excessive heat and direct sunlight to maintain potency.

Monosan is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s guidance on timing relative to meals.

Serious risks include severe hypotension, syncope, and rare allergic reactions. Patients should seek immediate medical attention if they experience fainting, a sudden drop in blood pressure, or signs of an allergic response.

Monosan should be avoided in patients with known hypersensitivity to isosorbide mononitrate or other nitrates, those using phosphodiesterase‑5 inhibitors, and individuals with severe anemia or uncontrolled hypotension unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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