Product image of Monosordil (Isosorbide 5 Mononitrate) supplied by GNH India

Monosordil

Active Ingredient:
Isosorbide 5 Mononitrate
Origin:
EU

Monosordil (Isosorbide 5 Mononitrate)

Isosorbide 5-mononitrate, the active ingredient in Monosordil, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed to relieve episodes of angina pectoris by reducing myocardial oxygen demand in adult patients, providing prophylactic control of chest pain during physical exertion or stress.

GNH India supplies Monosordil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured batches that meet EU regulatory standards and adhering to stringent manufacturing practices for reliable global distribution.

Manufacturer / TM Owner

Elpen Pharmaceutical Co. Inc.

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Indications & Clinical Uses

Monosordil (isosorbide 5‑mononitrate) belongs to the nitrate vasodilator class and is indicated for the management of angina pectoris, a condition characterized by chest discomfort due to myocardial ischemia.

  • Angina pectoris: provides prophylactic relief of chest pain by decreasing myocardial oxygen consumption and improving coronary blood flow.

How It Works

  • Isosorbide 5‑mononitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of arterial and venous vessels, producing vasodilation, reduced preload and afterload, and consequently lower myocardial oxygen demand.

Side Effects

Monosordil may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Headache: throbbing pain often occurring shortly after dosing.
  • Dizziness or light‑headedness: related to blood pressure reduction.
  • Flushing: warm sensation and reddening of the skin.
  • Hypotension: mild to moderate drop in blood pressure.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure fall requiring medical attention.
  • Syncope: transient loss of consciousness.
  • Myocardial infarction: rare but possible in susceptible patients.
  • Allergic reaction: rash, itching, or swelling.
  • Tachycardia: rapid heart rate accompanying hypotension.

Precautions & Warnings

When prescribing Monosordil, clinicians should consider several safety measures.

  • Dose titration: start with a low dose and increase gradually to minimise hypotension.
  • Concomitant nitrates: avoid using with other nitrate preparations to prevent additive vasodilation.
  • Phosphodiesterase‑5 inhibitors: contraindicated due to risk of severe hypotension.
  • Blood pressure monitoring: regularly assess to detect excessive drops.
  • Pregnancy and lactation: safety unknown; use only if benefit outweighs potential risk.
  • Store at ambient temperature: keep below 25 °C in the original container, protected from moisture.

Avoid Interactions

Monosordil can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): risk of profound hypotension.
  • Other nitrates (e.g., isosorbide dinitrate, nitroglycerin): additive vasodilatory effect.
  • Sodium nitrite: may cause excessive vasodilation.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, beta‑blockers, calcium channel blockers): may enhance blood‑pressure‑lowering effect.
  • Alcohol: can increase hypotensive response.
  • Diuretics: may potentiate volume depletion and hypotension.

Frequently Asked Questions

Monosordil contains isosorbide 5‑mononitrate and is prescribed to prevent and relieve episodes of angina pectoris. By lowering the heart’s oxygen demand, it helps reduce chest pain that occurs during physical activity or emotional stress.

The compound releases nitric oxide after oral absorption. Nitric oxide activates guanylate cyclase, increasing cyclic GMP levels in vascular smooth muscle, which causes the vessels to relax. This vasodilation reduces cardiac preload and afterload, decreasing myocardial oxygen consumption.

The dosage of Monosordil is individualized by the prescribing clinician based on the patient’s condition, response, and tolerance. Physicians typically start with a low dose and may adjust it gradually to achieve optimal symptom control while monitoring for side effects.

Safety data for isosorbide 5‑mononitrate during pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Monosordil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Monosordil belongs to the nitrate class, offering long‑acting vasodilation similar to isosorbide dinitrate but with a more stable plasma profile. Compared with beta‑blockers or calcium‑channel blockers, nitrates primarily reduce myocardial oxygen demand through preload reduction rather than heart‑rate control.

Store Monosordil at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Monosordil is taken orally as a tablet. Patients should swallow the tablet whole with a glass of water, usually once daily, unless the prescriber advises a different schedule. It is important to follow the healthcare provider’s instructions regarding timing and food.

The most serious adverse events include severe hypotension, syncope (fainting), myocardial infarction, and rare allergic reactions such as rash or swelling. Prompt medical attention is required if any of these symptoms occur.

Monosordil should be avoided in patients with known hypersensitivity to isosorbide 5‑mononitrate or other nitrates, those concurrently using phosphodiesterase‑5 inhibitors, or individuals with severe hypotension. Clinicians must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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