Product image of Monosordil (Isosorbide 5 Mononitrate) supplied by GNH India

Monosordil

Active Ingredient:
Isosorbide 5 Mononitrate
Origin:
EU

Monosordil (Isosorbide 5 Mononitrate)

Isosorbide 5-mononitrate, the active ingredient in Monosordil, is a nitrate vasodilator presented as an oral tablet for oral use. It is indicated for the prevention and treatment of angina pectoris in adults.
GNH India supplies Monosordil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Elpen Pharmaceutical Co. Inc.

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Indications & Clinical Uses

Monosordil belongs to the nitrate vasodilator class and is used to manage coronary artery disease‑related chest pain.

  • Angina pectoris: reduces the frequency and severity of chest pain episodes.
  • Chronic stable angina: improves exercise tolerance and delays onset of symptoms.
  • Coronary artery disease‑related chest pain: provides prophylactic relief of anginal attacks.

How It Works

  • Isosorbide 5‑mononitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of arterial and venous vessels, producing vasodilation, lowering cardiac preload and afterload, and thereby decreasing myocardial oxygen demand.

Side Effects

Isosorbide 5‑mononitrate may cause a range of adverse reactions, most of which are dose‑related and transient.

Common Side Effects

  • Headache: throbbing pain often occurring shortly after dosing.
  • Dizziness or light‑headedness: related to blood pressure reduction.
  • Flushing: warm sensation and reddening of the skin.
  • Hypotension: mild to moderate drop in blood pressure.
  • Nausea: occasional gastrointestinal upset.
  • Palpitations: awareness of heartbeat irregularities.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Syncope: fainting episodes due to inadequate cerebral perfusion.
  • Myocardial infarction: rare but possible in susceptible patients.
  • Allergic reaction: rash, itching, or swelling indicating hypersensitivity.
  • Methemoglobinemia: rare blood disorder causing reduced oxygen delivery.

Precautions & Warnings

Before initiating therapy with Monosordil, clinicians should consider several safety measures.

  • Cardiovascular assessment: evaluate baseline blood pressure and heart rate.
  • Concomitant nitrate use: avoid combining with other nitrates to prevent excessive hypotension.
  • Phosphodiesterase‑5 inhibitors: do not co‑administer with sildenafil, tadalafil, or similar agents.
  • Hepatic impairment: use with caution in patients with liver dysfunction.
  • Pregnancy and lactation: safety not established; weigh potential benefits against risks.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Isosorbide 5‑mononitrate can interact with several drug classes, influencing its safety profile.

Major Interactions (Avoid)

  • Other nitrates (e.g., nitroglycerin, isosorbide dinitrate): risk of profound hypotension.
  • Phosphodiesterase‑5 inhibitors (sildenafil, tadalafil, vardenafil): may cause severe blood pressure drops.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (beta‑blockers, ACE inhibitors, calcium channel blockers): additive blood pressure‑lowering effect.
  • Diuretics: may enhance orthostatic hypotension.
  • Alcohol: can increase vasodilatory effects and dizziness.

Frequently Asked Questions

Monosordil contains isosorbide 5‑mononitrate, a nitrate vasodilator prescribed to prevent and treat angina pectoris and chronic stable angina. It works by reducing the heart’s oxygen demand, helping patients avoid chest pain during physical activity or stress.

Isosorbide 5‑mononitrate is converted in the body to nitric oxide, which activates guanylate cyclase in vascular smooth muscle. This raises cyclic GMP levels, causing relaxation of arteries and veins, lowering cardiac preload and afterload, and ultimately decreasing myocardial oxygen consumption.

The appropriate dose of Monosordil is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Dosage adjustments are made individually, and patients should follow the exact regimen provided by their healthcare professional.

Safety data for isosorbide 5‑mononitrate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Monosordil, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Monosordil belongs to the nitrate class, offering a longer‑acting oral option compared with short‑acting nitroglycerin tablets. Unlike beta‑blockers or calcium‑channel blockers, nitrates primarily reduce myocardial oxygen demand through vasodilation, making them useful for patients who need prophylactic symptom control.

Monosordil should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, heat, and direct sunlight to maintain stability and potency throughout its shelf life.

Monosordil is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should follow the specific instructions given by their prescriber to ensure consistent absorption and effect.

The most serious risks include severe hypotension, syncope, and rare allergic reactions such as rash or anaphylaxis. Patients should seek immediate medical attention if they experience fainting, a sudden drop in blood pressure, or signs of an allergic response.

Monosordil is contraindicated in patients who have taken other nitrate medications within the past 24 hours, those using phosphodiesterase‑5 inhibitors, and individuals with known hypersensitivity to isosorbide derivatives. It should also be avoided in patients with severe hypotension or uncontrolled heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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