Product image of Monotrim (Trimethoprim) supplied by GNH India

Monotrim

Active Ingredient:
Trimethoprim
Origin:
EU

Monotrim (Trimethoprim)

Trimethoprim, the active ingredient in Monotrim, is an antibacterial presented as an oral tablet for systemic use. It is employed to treat bacterial infections of the urinary and respiratory tracts and is commonly prescribed for uncomplicated urinary tract infections in adults.

GNH India supplies Monotrim as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets.

Manufacturer / TM Owner

Chemidex Pharma Limited

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Indications & Clinical Uses

Trimethoprim is used to treat infections caused by susceptible bacteria in the urinary and respiratory systems.

  • Urinary tract infection: eradicates causative bacteria and resolves dysuria, frequency and urgency.
  • Respiratory tract infection: treats acute bacterial bronchitis and sinusitis by eliminating the pathogen.
  • Travelers' diarrhea: provides antibacterial therapy for uncomplicated travel‑associated diarrhoea, reducing stool frequency and abdominal cramping.

How It Works

  • Trimethoprim selectively inhibits bacterial dihydrofolate reductase, an enzyme required for the reduction of dihydrofolic acid to tetrahydrofolic acid. By blocking this step, the drug impairs folic acid synthesis, which is essential for bacterial DNA, RNA and protein production, ultimately halting bacterial growth and replication.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional episodes after dosing.
  • Loss of appetite: reduced desire to eat.
  • Rash: mild skin irritation or erythema.
  • Headache: transient dull headache.
  • Elevated liver enzymes: mild, reversible increase.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate discontinuation.
  • Agranulocytosis: marked drop in white blood cells, increasing infection risk.
  • Severe hepatic injury: jaundice or hepatitis.
  • Acute kidney injury: reduced renal function.
  • Hemolytic anemia in G6PD deficiency: rapid destruction of red blood cells.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Renal impairment: dose adjustment may be required.
  • Hepatic impairment: monitor liver function tests.
  • Pregnancy: safety category unknown; use only if benefits outweigh risks.
  • Breastfeeding: caution, as drug may be excreted in milk.
  • Allergic reactions: discontinue if hypersensitivity develops.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Trimethoprim may interact with several medicines.

Major Interactions (Avoid)

  • Methotrexate: increased toxicity due to overlapping folate inhibition.
  • Trimethoprim‑sulfamethoxazole combination: heightened risk of bone‑marrow suppression.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • High‑dose folic acid supplements: may reduce antibacterial efficacy.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: risk of hyperkalaemia.
  • ACE inhibitors: monitor serum potassium levels.
  • NSAIDs: may impair renal function, especially in dehydrated patients.

Frequently Asked Questions

Monotrim contains trimethoprim and is prescribed to treat bacterial infections of the urinary tract, certain respiratory infections such as acute bronchitis or sinusitis, and uncomplicated travelers' diarrhea caused by susceptible organisms.

Trimethoprim inhibits the bacterial enzyme dihydrofolate reductase, preventing the conversion of dihydrofolic acid to tetrahydrofolic acid. This blocks folic acid synthesis, which is essential for bacterial DNA, RNA and protein production, thereby stopping bacterial growth.

The dosage of Monotrim is determined by the prescribing clinician based on the infection type, severity, patient age, renal function and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional.

Trimethoprim’s pregnancy category is not definitively established; it should be used only when clearly needed and after risk‑benefit assessment by a physician. Caution is advised during breastfeeding because the drug can be excreted in milk.

To order Monotrim, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The most common alternative is the combination of trimethoprim with sulfamethoxazole (co‑trimoxazole). Monotrim provides trimethoprim alone, which may be preferred when sulfonamide sensitivity is a concern, but co‑trimoxazole often offers a broader spectrum against certain pathogens.

Store Monotrim at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Monotrim is taken orally with a glass of water. It can be taken with or without food, but patients should follow any specific instructions from their prescriber regarding timing relative to meals.

Serious adverse reactions include severe skin disorders such as Stevens‑Johnson syndrome, blood dyscrasias like agranulocytosis, acute liver injury, renal impairment, and hemolytic anemia in individuals with G6PD deficiency. Immediate medical attention is required if any of these occur.

Monotrim should be avoided in patients with known hypersensitivity to trimethoprim, severe renal or hepatic impairment without dose adjustment, and in individuals with G6PD deficiency due to the risk of hemolysis. Clinicians should also assess risks in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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