Monovo (Mometasone Furoate)

• Mometasone furoate is a potent topical corticosteroid used to manage inflammatory skin disorders such as psoriasis, eczema and various forms of dermatitis.
• Psoriasis: reduces plaque thickness, scaling, and erythema, leading to smoother skin and improved lesion appearance.
• Eczema: alleviates redness, itching, and inflammation, helping restore skin barrier function and patient comfort.
• Dermatitis: controls flare‑ups, decreases swelling and irritation, providing symptomatic relief and facilitating healing of affected areas.
• Pruritus: provides relief from itching associated with inflammatory skin conditions, enhancing patient comfort.

• Mometasone furoate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses pro‑inflammatory cytokine production, inhibits leukocyte migration, and reduces vascular permeability, resulting in potent anti‑inflammatory and immunosuppressive effects on the skin.

Mometasone furoate may cause local skin reactions, especially when applied to sensitive areas or used for prolonged periods.

Common Side Effects

• Skin irritation or burning sensation
• Itching or mild pruritus
• Dryness or flaking of the treated area
• Folliculitis or acne‑like eruptions
• Redness or erythema at the application site
• Mild hypertrichosis (increased hair growth)

Serious or Rare Side Effects

• Skin atrophy or thinning
• Telangiectasia (visible small blood vessels)
• Hypopigmentation or depigmentation
• Secondary bacterial, fungal or viral infection
• Systemic adrenal suppression with extensive use
• Allergic contact dermatitis or severe hypersensitivity reaction

When using Monovo, follow safety measures to minimize risks.

• Avoid application on infected or ulcerated skin: assess for bacterial or fungal infection before use.
• Limit duration of therapy: prolonged use may increase risk of systemic absorption and related effects.
• Do not apply to large body surface areas: restrict to affected lesions to reduce systemic exposure.
• Use caution in children: higher per‑kilogram absorption may occur, requiring close monitoring.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Mometasone furoate can interact with other agents that affect steroid metabolism or skin absorption.

Major Interactions (Avoid)

• Systemic corticosteroids: concurrent use may increase risk of systemic glucocorticoid effects.
• Potent CYP3A4 inhibitors: may alter local steroid metabolism, potentially enhancing local effects.

Moderate Interactions (Monitor Closely)

• Antifungal agents (e.g., ketoconazole): may increase local steroid concentration.
• Skin barrier disruptors (e.g., harsh soaps or exfoliants): may enhance percutaneous absorption.
• Live vaccines: topical steroids may reduce local immune response, potentially affecting vaccine efficacy.