Product image of Monozide (Fosinopril Sodium, Hydrochlorothiazide) supplied by GNH India

Monozide

Active Ingredient:
Fosinopril Sodium, Hydrochlorothiazide
Origin:
EU

Monozide (Fosinopril Sodium, Hydrochlorothiazide)

Fosinopril sodium, the active ingredient in Monozide, is an ACE inhibitor presented as an oral tablet for systemic use. It is combined with hydrochlorothiazide to treat hypertension and edema associated with high blood pressure in adult patients.

GNH India supplies Monozide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmaswiss Česká Republika S.R.O.

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Indications & Clinical Uses

  • Monozide is indicated for conditions that involve elevated blood pressure or fluid retention, acting through combined ACE inhibition and diuretic mechanisms.
  • Hypertension: lowers systolic and diastolic blood pressure to reduce cardiovascular risk.
  • Edema associated with hypertension: promotes diuresis to decrease excess fluid volume.
  • Combined blood‑pressure control: provides dual action of ACE inhibition and thiazide diuresis for patients needing both effects.

How It Works

  • Fosinopril sodium blocks the angiotensin‑converting enzyme, preventing formation of angiotensin II and reducing vasoconstriction and aldosterone release. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, increasing urinary excretion of water and electrolytes, which together lower peripheral resistance and plasma volume, resulting in blood‑pressure reduction.

Side Effects

Monozide may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dizziness or light‑headedness, especially after the first dose.
  • Persistent dry cough due to ACE inhibition.
  • Increased urinary frequency or volume.
  • Headache or mild fatigue.

Serious or Rare Side Effects

  • Angioedema involving face, lips, tongue or airway.
  • Severe dehydration or electrolyte imbalance (e.g., low potassium).
  • Acute renal impairment or sudden rise in serum creatinine.
  • Marked hypotension leading to syncope.

Precautions & Warnings

  • Before initiating Monozide, clinicians should consider several safety measures.
  • Monitor renal function: check serum creatinine and eGFR periodically.
  • Check electrolytes: especially potassium and sodium levels.
  • Avoid use in pregnancy: classified as Category D due to fetal risk.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Adjust dose for elderly patients: start low and titrate slowly.
  • Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Monozide can interact with several drug classes, influencing efficacy or safety.

Major Interactions (Avoid)

  • Aliskiren combined with ACE inhibitors (risk of renal dysfunction and hyperkalemia).
  • Potassium‑sparing diuretics or supplements (excess potassium accumulation).
  • NSAIDs (may blunt antihypertensive effect and impair renal function).

Moderate Interactions (Monitor Closely)

  • Lithium (increased lithium levels, risk of toxicity).
  • Beta‑blockers or other antihypertensives (additive blood‑pressure lowering, monitor for hypotension).
  • Antidiabetic agents (possible enhancement of hypoglycaemic effect).

Frequently Asked Questions

Monozide is a prescription medication that combines fosinopril sodium, an ACE inhibitor, with hydrochlorothiazide, a thiazide diuretic. It is used to lower high blood pressure and to reduce fluid retention (edema) that can accompany hypertension.

Fosinopril sodium blocks the angiotensin‑converting enzyme, which prevents the conversion of angiotensin I to the potent vasoconstrictor angiotensin II. This leads to relaxed blood vessels, reduced aldosterone release, and ultimately lower blood pressure.

The specific dose of Monozide is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and other individual factors. Patients should follow the dose prescribed by their healthcare professional.

Monozide is classified as Pregnancy Category D, indicating evidence of risk to the fetus. It should be avoided during pregnancy unless the potential benefit justifies the risk. Safety during breastfeeding has not been established, so use only if clearly needed and advised by a physician.

To order Monozide, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Monozide offers a dual mechanism by combining an ACE inhibitor with a thiazide diuretic, providing both vasodilation and diuresis. This can simplify therapy compared with taking two separate drugs, and may improve blood‑pressure control in patients who need both actions.

Monozide tablets should be stored below 25 °C in their original packaging, protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of children.

Monozide is taken orally, usually once daily or as directed by a healthcare professional. It should be swallowed whole with a glass of water, and can be taken with or without food according to the prescriber’s advice.

Serious risks include angioedema (swelling of the face, lips, tongue or airway), severe dehydration or electrolyte disturbances, acute kidney injury, and marked hypotension that can cause fainting. Patients should seek immediate medical attention if any of these occur.

Monozide should not be used by patients with a known hypersensitivity to fosinopril, hydrochlorothiazide, or any component of the formulation. It is also contraindicated in pregnancy, in patients with severe renal impairment, and in those taking aliskiren together with an ACE inhibitor.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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