Product image of Montelucaste Apilif (Montelukast) supplied by GNH India

Montelucaste Apilif

Active Ingredient:
Montelukast
Origin:
EU

Montelucaste Apilif (Montelukast)

Montelukast, the active ingredient in Montelucaste Apilif, is a leukotriene receptor antagonist presented as an oral dosage form for oral use. It is used to manage asthma, allergic rhinitis and exercise‑induced bronchoconstriction in appropriate patients.

GNH India supplies Montelucaste Apilif as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tecnimede - Sociedade Técnico-Medicinal, Sa

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Indications & Clinical Uses

Montelukast acts on the leukotriene pathway to control respiratory allergic conditions.

  • Asthma: improves control of chronic airway inflammation and reduces bronchoconstriction.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching caused by allergen exposure.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing triggered by physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 from binding. This inhibition reduces leukotriene‑mediated bronchoconstriction, vascular permeability, and inflammatory cell recruitment in the airways, thereby improving respiratory function and decreasing allergic inflammation.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Abdominal pain: occasional discomfort.
  • Nausea: transient episodes.
  • Diarrhea: loose stools.

Serious or Rare Side Effects

  • Allergic reactions: rash, angioedema, or anaphylaxis.
  • Neuropsychiatric events: depression, mood changes, or suicidal thoughts.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before prescribing Montelucaste Apilif, consider the following safety measures.

  • Monitor mood changes: watch for depression or suicidal ideation.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Assess asthma control: ensure baseline therapy is optimized.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Montelukast may interact with other medicines; awareness of interaction severity helps guide monitoring.

Major Interactions (Avoid)

  • Rifampin: strong CYP3A4 inducer that can lower montelukast exposure.
  • Phenobarbital: enzyme inducer reducing therapeutic levels.

Moderate Interactions (Monitor Closely)

  • Fluconazole: CYP2C9 inhibitor may increase plasma concentrations.
  • Zafirlukast: concurrent leukotriene modifiers can increase risk of side effects.
  • Beta‑agonists: additive bronchodilatory effect may require dose adjustment.

Frequently Asked Questions

Montelucaste Apilif contains montelukast, which is prescribed to treat asthma, allergic rhinitis, and exercise‑induced bronchoconstriction. It works by reducing airway inflammation and preventing bronchospasm, helping patients achieve better respiratory control.

Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 from triggering bronchoconstriction and inflammation. By inhibiting this pathway, it reduces airway narrowing, mucus production, and allergic symptoms.

The specific dose of Montelucaste Apilif is determined by the prescribing clinician based on the patient’s age, condition severity, and response to therapy. Only a qualified healthcare professional should set the dosing regimen.

Safety data for montelukast in pregnancy and lactation are limited. The prescriber should weigh potential benefits against risks and consider alternative therapies if appropriate. Women who are pregnant or nursing should discuss use with their healthcare provider.

To request Montelucaste Apilif, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients with allergic components or exercise‑induced symptoms, but it does not replace rescue bronchodilators for acute attacks.

Montelucaste Apilif should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole; do not crush, chew, or split unless specifically instructed.

Serious risks include neuropsychiatric events such as depression, suicidal thoughts, and mood changes, as well as severe allergic reactions like anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Montelucaste Apilif is contraindicated in individuals with known hypersensitivity to montelukast or any of the tablet’s excipients. It should also be used with caution in patients with severe liver impairment or a history of neuropsychiatric disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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