Product image of Montelucaste Sandoz (Montelukast) supplied by GNH India

Montelucaste Sandoz

Active Ingredient:
Montelukast
Origin:
EU

Montelucaste Sandoz (Montelukast)

Montelukast, the active ingredient in Montelucaste Sandoz, is a leukotriene receptor antagonist presented as an oral tablet for oral administration. It helps control chronic asthma, prevent exercise‑induced bronchoconstriction, and relieve symptoms of seasonal or perennial allergic rhinitis in both adult and pediatric patients. The medication works by blocking cysteinyl leukotriene receptors in the airways, reducing inflammation and narrowing of the bronchial tubes.

GNH India supplies Montelucaste Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Farmaceutica Lda.

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Indications & Clinical Uses

Montelukast is indicated for conditions involving leukotriene‑mediated airway inflammation and allergic symptoms.

  • Asthma: provides maintenance therapy to reduce the frequency and severity of asthma attacks.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching associated with seasonal or perennial allergic rhinitis.
  • Exercise‑induced bronchoconstriction: prevents narrowing of the airways triggered by physical activity.

How It Works

  • Montelukast selectively antagonizes the cysteinyl leukotriene receptor CysLT1 located on smooth‑muscle, endothelial and inflammatory cells in the respiratory tract. By blocking the binding of leukotriene D4 and related mediators, it inhibits leukotriene‑induced bronchoconstriction, vascular permeability and eosinophilic inflammation, thereby improving airway patency and reducing allergic responses.

Side Effects

Montelukast may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Upper respiratory tract infection

Serious or Rare Side Effects

  • Neuropsychiatric events (e.g., agitation, depression, suicidal thoughts)
  • Allergic reactions (e.g., rash, angioedema, anaphylaxis)
  • Hepatotoxicity (elevated liver enzymes, hepatitis)

Precautions & Warnings

When prescribing Montelukast, clinicians should consider several safety measures.

  • Assess asthma control before initiating: ensure the patient is on appropriate inhaled therapy.
  • Monitor for neuropsychiatric symptoms: report mood changes, depression or suicidal thoughts.
  • Use with caution in hepatic impairment: adjust if liver function is abnormal.
  • Avoid in patients with known hypersensitivity to montelukast or formulation components.
  • Pregnancy and lactation: discuss risks with the prescriber; data are limited.
  • Store at ambient temperature: keep below 25 °C, retain in the original container, protect from moisture and light.

Avoid Interactions

Montelukast can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Phenobarbital: may reduce plasma concentrations of montelukast.
  • Rifampin: induces metabolism, lowering efficacy.
  • Ketoconazole: may increase montelukast levels, raising risk of adverse effects.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential alteration of anticoagulant effect; monitor INR.
  • Beta‑agonists: additive bronchodilation, monitor clinical response.
  • Antidepressants (SSRIs): possible increase in neuropsychiatric side effects.

Frequently Asked Questions

Montelucaste Sandoz contains montelukast, which is prescribed for maintenance therapy of asthma, relief of allergic rhinitis symptoms, and prevention of exercise‑induced bronchoconstriction. It targets leukotriene‑mediated inflammation in the airways, helping to control chronic respiratory conditions.

Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth‑muscle and inflammatory cells. By preventing leukotriene D4 from binding, it reduces bronchoconstriction, vascular leakage, and eosinophilic inflammation, which together improve breathing and lessen allergic symptoms.

The specific dose of Montelucaste Sandoz is determined by the prescribing clinician based on the patient’s age, condition severity, and treatment goals. Healthcare professionals follow approved labeling and clinical guidelines to set the appropriate regimen.

Safety data for montelukast in pregnancy and lactation are limited. Prescribers should weigh potential benefits against unknown risks and discuss them with the patient. If treatment is necessary, it should be used only under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients who need additional control of leukotriene‑driven inflammation, but it does not replace rescue bronchodilators for acute attacks.

Montelucaste Sandoz should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and discard any product that appears discoloured or damaged.

The medication is taken orally, usually once daily in the evening, with or without food. Patients should swallow the tablet whole and follow the prescriber’s instructions regarding timing and any concomitant therapies.

Serious adverse events, although rare, include neuropsychiatric reactions such as agitation, depression or suicidal thoughts, severe allergic responses like anaphylaxis, and liver injury indicated by elevated enzymes. Any of these symptoms warrant immediate medical evaluation.

Montelucaste Sandoz is contraindicated in individuals with known hypersensitivity to montelukast or any of the tablet’s excipients. Caution is advised for patients with severe hepatic impairment, and it should be used only under medical guidance during pregnancy or lactation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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