Product image of Montelucaste Sandoz (Montelukast) supplied by GNH India

Montelucaste Sandoz

Active Ingredient:
Montelukast
Origin:
EU

Montelucaste Sandoz (Montelukast)

Montelukast, the active ingredient in Montelucaste Sandoz, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is used for maintenance therapy of asthma, relief of allergic rhinitis symptoms, and prevention of exercise‑induced bronchoconstriction in adults and children.

GNH India supplies Montelucaste Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Farmacêutica Lda.

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Indications & Clinical Uses

Montelukast is a leukotriene receptor antagonist that addresses inflammatory airway conditions.

  • Asthma (maintenance therapy): reduces frequency and severity of asthma attacks and improves overall lung function.
  • Allergic rhinitis: alleviates nasal congestion, sneezing, and itchy watery eyes caused by seasonal or perennial allergens.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing that occurs during physical activity, allowing better exercise tolerance.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth muscle and inflammatory cells. By antagonizing this receptor, it inhibits the actions of leukotriene D4 and related mediators, reducing bronchoconstriction, mucus secretion, vascular permeability, and eosinophilic inflammation that contribute to asthma and allergic rhinitis symptoms.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate pain often reported.
  • Abdominal pain: discomfort or cramping in the stomach area.
  • Cough: occasional dry or productive cough.
  • Sore throat: irritation or pain in the throat.
  • Nausea: feeling of queasiness or urge to vomit.
  • Dizziness: light‑headed sensation.

Serious or Rare Side Effects

  • Allergic reactions: rash, angioedema, or anaphylaxis.
  • Mood changes: depression, anxiety, or suicidal thoughts.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Bronchospasm: paradoxical worsening of breathing.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

When prescribing Montelucaste Sandoz, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use; benefits must outweigh potential risks.
  • Liver disease: monitor hepatic function as metabolism occurs in the liver.
  • Concomitant CYP3A4 inhibitors: may increase drug exposure; dose adjustment may be needed.
  • Not for acute asthma attacks: use a short‑acting bronchodilator for rescue.
  • Age considerations: safety established in children aged 12 months and older; follow pediatric guidance.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Montelukast may interact with other medicines; awareness of interaction severity helps guide monitoring.

Major Interactions (Avoid)

  • Ritonavir: potent CYP3A4 inhibitor that can markedly increase montelukast plasma levels.
  • Phenobarbital: strong enzyme inducer that may reduce therapeutic effectiveness.

Moderate Interactions (Monitor Closely)

  • Fluconazole: moderate CYP3A4 inhibition may raise montelukast concentrations.
  • Carbamazepine: enzyme induction can lower drug exposure.
  • Warfarin: possible effect on anticoagulation; monitor INR when co‑administered.

Frequently Asked Questions

Montelucaste Sandoz contains montelukast, which is indicated for maintenance therapy of asthma, relief of allergic rhinitis symptoms, and prevention of exercise‑induced bronchoconstriction. It helps control chronic airway inflammation and reduces the frequency of asthma attacks and allergy‑related nasal symptoms.

Montelukast works by selectively blocking the cysteinyl leukotriene receptor CysLT1 on airway smooth muscle and inflammatory cells. This inhibition prevents leukotriene D4 and related mediators from causing bronchoconstriction, mucus production, and vascular leakage, thereby reducing airway inflammation and hyper‑responsiveness.

The appropriate dose of Montelucaste Sandoz is determined by the prescribing healthcare professional based on the patient’s age, condition, and response to therapy. Dosage forms and strengths are selected to match the clinician’s recommendation; patients should follow the prescribed regimen exactly.

Safety of montelukast during pregnancy or lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and discuss any concerns with the patient. If used while breastfeeding, monitoring the infant for adverse effects is advisable.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients who prefer a tablet, have difficulty using inhalers, or need additional control of allergic rhinitis. Clinical guidelines often recommend it as add‑on therapy rather than a sole replacement for inhaled steroids.

Montelucaste Sandoz tablets should be stored at room temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in high‑humidity environments such as bathrooms.

The medication is taken orally, usually once daily in the evening, with or without food as directed by the prescriber. Swallow the tablet whole; do not crush, chew, or split unless specifically instructed.

Serious risks, though rare, include severe allergic reactions such as rash, angioedema, or anaphylaxis, as well as neuropsychiatric events like depression, anxiety, or suicidal thoughts. Patients should seek immediate medical attention if they experience any of these symptoms.

Montelucaste Sandoz should be avoided in individuals with known hypersensitivity to montelukast or any component of the formulation. It is also not suitable for acute asthma attacks; patients experiencing sudden breathing difficulty should use a rescue inhaler instead of this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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