Product image of Montelukast supplied by GNH India

Montelukast

Active Ingredient:
Montelukast
Origin:
EU

Montelukast

Montelukast, the active ingredient in this product, is a leukotriene receptor antagonist presented as an oral tablet for oral administration. It selectively blocks cysteinyl leukotriene receptors, helping to control bronchoconstriction and inflammation associated with asthma, allergic rhinitis, and exercise‑induced bronchoconstriction in both adults and children.

GNH India supplies Montelukast as a licensed, GMP‑qualified, GDP‑compliant international pharmaceutical supplier, providing the medication to hospitals, pharmacies and clinics worldwide under strict quality standards.

Manufacturer / TM Owner

N.V. Organon

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Indications & Clinical Uses

Montelukast is indicated for conditions involving leukotriene‑mediated airway inflammation.

  • Asthma: reduces frequency of symptoms and improves lung function.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching.
  • Exercise‑induced bronchoconstriction: prevents narrowing of airways during physical activity.

How It Works

  • Montelukast acts as a selective antagonist of the cysteinyl leukotriene receptor CysLT1. By binding to this receptor, it blocks the action of leukotriene D4, a potent mediator of bronchoconstriction, mucus secretion, and airway inflammation, thereby reducing airway narrowing and inflammatory responses in the respiratory tract.

Side Effects

Montelukast may cause adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Nausea

Serious or Rare Side Effects

  • Allergic reactions such as rash or angioedema
  • Mood changes including depression or suicidal thoughts
  • Elevated liver enzymes
  • Eosinophilic granulomatosis with polyangiitis (Churg‑Strauss syndrome)

Precautions & Warnings

When prescribing Montelukast, clinicians should consider several safety aspects.

  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Breastfeeding: unknown; evaluate potential risk to infant.
  • Hepatic impairment: use with caution and monitor liver function.
  • Neuropsychiatric events: monitor for mood changes, depression, or suicidal thoughts.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store below 25°C: keep in original container, protect from moisture.

Avoid Interactions

Montelukast can interact with other medicines; interactions vary in clinical significance.

Major Interactions (Avoid)

  • Phenobarbital: may reduce plasma concentrations of Montelukast.
  • Rifampin: may decrease efficacy by inducing metabolism.
  • Ketoconazole: may increase Montelukast levels.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of anticoagulant effect; monitor INR.
  • Beta‑agonists: additive bronchodilation; monitor response.
  • Antidepressants: potential for increased neuropsychiatric effects.

Frequently Asked Questions

Montelukast is prescribed to manage asthma, allergic rhinitis, and exercise‑induced bronchoconstriction. By targeting leukotriene pathways, it helps reduce airway inflammation, prevent bronchospasm, and relieve nasal symptoms such as congestion, sneezing, and itching.

Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1. This inhibition prevents leukotriene D4 from binding, which in turn reduces bronchoconstriction, mucus production, and inflammatory cell recruitment in the respiratory tract.

The appropriate dose of Montelukast is determined by the prescribing healthcare professional based on the patient’s age, condition, and clinical response. Typical regimens may vary, but the exact dosage and frequency should always follow the prescriber’s instructions.

Safety data for Montelukast in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or other leukotriene blockers such as zafirlukast. It is generally well‑tolerated and convenient for once‑daily dosing, but the choice depends on individual disease severity, response, and physician preference.

Montelukast tablets should be stored below 25 °C in their original packaging, protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of children to maintain product stability and potency.

Montelukast is taken orally as a tablet, swallowed whole with or without food. The tablet should be consumed at the same time each day, and patients should follow the dosing schedule prescribed by their healthcare professional.

Serious adverse events include allergic reactions such as rash or angioedema, neuropsychiatric effects like depression or suicidal thoughts, elevated liver enzymes, and rare conditions such as eosinophilic granulomatosis with polyangiitis. Any of these symptoms warrant immediate medical attention.

Montelukast is contraindicated in individuals with known hypersensitivity to the drug or any of its excipients. Patients with a history of severe neuropsychiatric disorders or uncontrolled liver disease should discuss risks with their clinician before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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