Product image of Montelukast supplied by GNH India

Montelukast

Active Ingredient:
Montelukast
Origin:
EU

Montelukast

Montelukast, the active ingredient in Montelukast, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is employed in the maintenance treatment of asthma, relief of allergic rhinitis symptoms, and prevention of exercise‑induced bronchoconstriction in appropriate patients.

GNH India supplies Montelukast as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and providing reliable global logistics for consistent product availability and comprehensive regulatory compliance support.

Manufacturer / TM Owner

N.V. Organon

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Indications & Clinical Uses

Montelukast is a leukotriene receptor antagonist used to manage several allergic and respiratory conditions.

  • Asthma: reduces frequency of asthma attacks and improves overall disease control.
  • Allergic rhinitis: alleviates nasal congestion, sneezing, itching and rhinorrhea.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing triggered by physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes from binding to airway smooth‑muscle and inflammatory cells. This inhibition reduces leukotriene‑mediated bronchoconstriction, vascular permeability, mucus secretion, and eosinophilic inflammation, thereby improving airway patency and decreasing allergic inflammation.

Side Effects

Montelukast may cause a range of adverse reactions.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Nasopharyngitis

Serious or Rare Side Effects

  • Mood changes, including depression or suicidal thoughts
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Angioedema or severe allergic reactions

Precautions & Warnings

When prescribing Montelukast, consider the following safety measures.

  • Assess asthma control before initiating therapy: ensure baseline stability.
  • Monitor for neuropsychiatric events: watch for mood swings, depression, or suicidal ideation.
  • Use caution in patients with hepatic impairment: dose adjustment may be required.
  • Review concomitant medications for potential interactions that could alter exposure.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Montelukast can interact with several medicines; awareness helps maintain therapeutic effectiveness.

Major Interactions (Avoid)

  • Rifampin: strong enzyme inducer that lowers montelukast plasma levels.
  • Phenobarbital: induces metabolism, reducing drug exposure.
  • Carbamazepine: enzyme induction may decrease efficacy.
  • St. John’s wort: herbal inducer that can reduce montelukast concentrations.

Moderate Interactions (Monitor Closely)

  • Fluconazole: moderate CYP inhibition may increase exposure.
  • Erythromycin: can modestly raise montelukast levels.
  • Warfarin: monitor INR as montelukast may affect anticoagulation control.

Frequently Asked Questions

Montelukast is prescribed for the long‑term management of asthma, to relieve symptoms of allergic rhinitis, and to prevent exercise‑induced bronchoconstriction. It works by blocking leukotrienes, which are inflammatory mediators that contribute to airway narrowing and allergic symptoms.

Montelukast selectively antagonizes the cysteinyl leukotriene receptor CysLT1 on airway smooth muscle and inflammatory cells. By preventing leukotriene binding, it reduces bronchoconstriction, mucus production, vascular leakage, and eosinophilic inflammation, leading to improved breathing and reduced allergic responses.

The appropriate dose of Montelukast is determined by the prescribing healthcare professional based on the patient’s age, weight, and specific indication. Dosage forms may include tablets, chewable tablets, or granules, and the prescriber will provide exact instructions.

Safety data for Montelukast in pregnancy are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies any potential risk to the fetus. Breastfeeding mothers should consult their physician, as the drug does pass into breast milk.

To order Montelukast, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists. It is particularly useful for patients with aspirin‑sensitive asthma or those who need an add‑on therapy, but it does not replace rescue bronchodilators for acute attacks.

Montelukast should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Montelukast is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with water; chewable or granule forms are mixed with a small amount of soft food as directed by the prescriber.

Serious risks include neuropsychiatric events such as depression, suicidal thoughts, or mood changes, as well as rare severe skin reactions like Stevens‑Johnson syndrome and angioedema. Patients should seek immediate medical attention if they experience any of these symptoms.

Montelukast is contraindicated in individuals with known hypersensitivity to the drug or any of its excipients. Caution is advised for patients with severe hepatic impairment, and it should not be used as a rescue medication for acute bronchospasm.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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