Product image of Montelukast Accord (Montelukast) supplied by GNH India

Montelukast Accord

Active Ingredient:
Montelukast
Origin:
EU

Montelukast Accord (Montelukast)

Montelukast, the active ingredient in Montelukast Accord, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is indicated for the long‑term management of asthma, relief of allergic rhinitis symptoms, and prevention of exercise‑induced bronchoconstriction in both adult and pediatric patients as prescribed by a qualified healthcare professional.

GNH India supplies Montelukast Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and tertiary care centers worldwide, including both public and private healthcare networks.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

  • Montelukast acts on the leukotriene pathway to control airway inflammation and bronchoconstriction.
  • Asthma: improves long‑term control of symptoms and reduces exacerbations.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching associated with seasonal or perennial allergens.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing triggered by physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth‑muscle cells, mast cells and eosinophils. By antagonizing this receptor, it prevents leukotriene‑mediated bronchoconstriction, vascular permeability, mucus secretion and inflammatory cell recruitment, thereby reducing airway hyper‑responsiveness and allergic inflammation. The inhibition is dose‑dependent and persists for the dosing interval, allowing once‑daily administration. This pharmacologic action distinguishes it from β2‑agonists, which provide acute bronchodilation, and from corticosteroids, which suppress broader inflammatory pathways.

Side Effects

Montelukast may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Nausea

Serious or Rare Side Effects

  • Angioedema
  • Neuropsychiatric events (e.g., agitation, depression, suicidal thoughts)
  • Hepatic injury

Precautions & Warnings

Montelukast should be used with attention to specific safety considerations.

  • Dose adjustment: not required for renal impairment but use caution in severe hepatic impairment.
  • Acute asthma: not indicated for immediate relief of bronchospasm; prescribe a rescue inhaler.
  • Pregnancy: only if potential benefit justifies potential risk to fetus.
  • Hypersensitivity: discontinue if signs of allergic reaction occur.
  • Store below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Montelukast may interact with other medicines; review concomitant therapy.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): may increase montelukast plasma concentrations.
  • Phenobarbital or rifampin: may reduce efficacy by inducing metabolism.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase risk of rash.
  • Antidepressants (e.g., fluoxetine): possible additive neuropsychiatric effects.
  • Warfarin: monitor INR as montelukast may affect coagulation parameters.

Frequently Asked Questions

Montelukast Accord contains the leukotriene receptor antagonist montelukast and is prescribed to help control chronic asthma, relieve symptoms of allergic rhinitis, and prevent exercise‑induced bronchoconstriction. It is used as part of a long‑term management plan under the supervision of a qualified healthcare professional.

Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1, which is activated by leukotrienes released during allergic and inflammatory responses. By inhibiting this receptor, the drug reduces bronchoconstriction, mucus production, vascular leakage, and recruitment of inflammatory cells, thereby improving airway patency and reducing allergic symptoms.

The dosage of Montelukast Accord is individualized by the prescribing clinician based on the patient’s age, weight, indication and overall treatment plan. Healthcare providers determine the appropriate strength, frequency and duration, and patients should follow the prescription label exactly.

Safety data for montelukast in pregnancy are limited; it should only be used when the potential benefit to the mother outweighs any possible risk to the fetus. Montelukast is excreted in breast milk in small amounts, so breastfeeding mothers should discuss risks and alternatives with their physician.

To request Montelukast Accord, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Montelukast and inhaled corticosteroids target different aspects of airway disease. Montelukast blocks leukotriene‑mediated inflammation and is taken orally once daily, making it useful for patients who cannot tolerate inhalers or need additional control. Inhaled corticosteroids act directly on airway epithelium to suppress a broader range of inflammatory mediators and remain the first‑line therapy for many asthma patients.

Montelukast Accord tablets should be stored below 25 °C (77 °F) in their original container, protected from moisture, heat and direct sunlight. Keep the product out of reach of children and do not use it after the expiry date printed on the packaging.

Montelukast Accord is taken orally, usually once daily in the evening, with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water; it is not intended for crushing, chewing, or splitting unless specifically advised by a healthcare professional.

Serious adverse reactions, although rare, include angioedema, severe neuropsychiatric events such as agitation, depression or suicidal thoughts, and hepatic injury. Patients should seek immediate medical attention if they experience swelling of the face or throat, mood changes, jaundice, or any signs of an allergic reaction.

Montelukast Accord is contraindicated in individuals with known hypersensitivity to montelukast or any of the tablet’s excipients. It should also be avoided in patients who require immediate relief of acute bronchospasm, as it is not a rescue medication. Clinicians should assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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