Product image of Montelukast Accord (Montelukast Sodium) supplied by GNH India

Montelukast Accord

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Accord (Montelukast Sodium)

Montelukast, the active ingredient in Montelukast Accord, is a leukotriene receptor antagonist presented as a tablet for oral use. It treats asthma, allergic rhinitis, and exercise‑induced bronchoconstriction in adults and children.

GNH India supplies Montelukast Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Montelukast is a leukotriene receptor antagonist that modulates inflammatory pathways in respiratory disorders.

  • Asthma: improves long‑term control and reduces the frequency of exacerbations.
  • Allergic rhinitis: relieves nasal congestion, sneezing and itchy eyes.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing during physical activity.

How It Works

  • Montelukast selectively antagonizes the cysteinyl leukotriene receptor CysLT1, blocking the action of leukotriene D4. This inhibition reduces leukotriene‑mediated bronchoconstriction, vascular permeability, and inflammatory cell recruitment in the airways, thereby improving respiratory function and decreasing allergic inflammation.

Side Effects

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Nasopharyngitis

Serious or Rare Side Effects

  • Allergic reactions such as angioedema or urticaria
  • Neuropsychiatric events including agitation, depression or suicidal thoughts
  • Elevation of hepatic enzymes
  • Eosinophilic granulomatosis with polyangiitis

Precautions & Warnings

Before prescribing Montelukast, clinicians should consider several safety aspects.

  • Assess asthma control before initiating: ensure the patient is on appropriate inhaled therapy.
  • Monitor for neuropsychiatric symptoms: report any mood changes or suicidal thoughts promptly.
  • Avoid use in patients with known hypersensitivity to montelukast or its excipients.
  • Use with caution in hepatic impairment: consider dose adjustment if necessary.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Montelukast may interact with other medicines, requiring attention to potential changes in efficacy or safety.

Major Interactions (Avoid)

  • Phenobarbital, rifampin, carbamazepine: may markedly reduce montelukast plasma concentrations.
  • Erythromycin, ketoconazole: may increase montelukast levels and risk of side effects.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of INR; monitor coagulation parameters.
  • Theophylline: additive bronchodilator effect; observe clinical response.
  • Beta‑agonists: no significant pharmacokinetic interaction, but monitor overall asthma control.

Frequently Asked Questions

Montelukast Accord is indicated for the maintenance treatment of asthma, relief of symptoms of allergic rhinitis, and prevention of exercise‑induced bronchoconstriction. It helps control chronic airway inflammation and reduces the frequency of asthma attacks and allergy‑related nasal symptoms.

Montelukast blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotriene D4 from binding. This stops leukotriene‑driven bronchoconstriction, mucus production, and inflammatory cell recruitment, leading to improved airway patency and reduced allergic inflammation.

The appropriate dose of Montelukast Accord is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of disease, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Montelukast during pregnancy and lactation are limited. The drug should be used only if the potential benefit justifies any potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their healthcare provider.

To order Montelukast Accord, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast is a leukotriene receptor antagonist, whereas inhaled corticosteroids target a broader range of inflammatory pathways. Montelukast is often used as an add‑on therapy for patients whose asthma is not fully controlled with inhaled steroids, or as an alternative for those who cannot tolerate steroids. The two classes have different safety profiles and mechanisms.

Montelukast Accord should be stored at ambient temperature below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and avoid storing them in bathrooms or other humid environments.

Montelukast Accord is taken orally as a tablet. The tablet should be swallowed whole with a glass of water, and it may be taken with or without food. Patients should follow the dosing schedule prescribed by their clinician.

Serious risks include severe allergic reactions such as angioedema or urticaria, neuropsychiatric events like agitation, depression or suicidal thoughts, and rare hepatic abnormalities. Any signs of these conditions should prompt immediate medical evaluation.

Montelukast Accord should not be used by individuals with a known hypersensitivity to montelukast sodium or any of the tablet’s excipients. Caution is also advised for patients with severe hepatic impairment, and it is not recommended for acute asthma attacks where rapid bronchodilation is required.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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