Montelukast Accord (Montelukast Sodium)

Montelukast Accord, a leukotriene receptor antagonist, is used to manage several respiratory conditions that involve leukotriene‑mediated inflammation and bronchoconstriction.

• Asthma: Reduces frequency and severity of bronchospasm, improves lung function and decreases need for rescue inhalers.
• Allergic rhinitis: Alleviates nasal congestion, sneezing, itching and watery eyes associated with seasonal or perennial allergens.
• Exercise‑induced bronchoconstriction: Prevents airway narrowing during physical activity, enhancing exercise tolerance and reducing post‑exercise respiratory symptoms.

• Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth‑muscle cells, mast cells and eosinophils. By preventing leukotriene D4 and related mediators from binding, it inhibits bronchoconstriction, mucus secretion and inflammatory cell recruitment, thereby reducing airway hyper‑responsiveness and allergic inflammation. The antagonism is dose‑dependent and persists for the duration of the dosing interval, providing sustained protection against leukotriene‑driven airway changes.

Montelukast may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

• Headache: Mild to moderate pain often reported during early treatment.
• Abdominal pain: Discomfort or cramps in the stomach region.
• Cough: Persistent dry cough without infection.
• Dyspepsia: Indigestion or feeling of fullness.
• Diarrhea: Loose stools occurring intermittently.
• Fatigue: Generalized tiredness or lack of energy.

Serious or Rare Side Effects

• Neuropsychiatric events: Mood changes, agitation, depression or suicidal thoughts.
• Allergic reactions: Rash, itching, swelling or anaphylaxis.
• Hepatic enzyme elevation: Increased liver function test values.
• Angioedema: Swelling of face, lips or tongue.
• Stevens‑Johnson syndrome: Severe skin blistering and mucosal involvement.

Before initiating therapy, consider the following safety measures.

• Pregnancy: Use only if clearly needed and prescribed by a qualified practitioner.
• Breastfeeding: Assess risk versus benefit; consult a healthcare professional.
• Renal impairment: Monitor renal function; dosage adjustment may be required.
• Hepatic impairment: Use with caution; monitor liver enzymes.
• Concomitant medications: Review all current drugs for potential interactions.
• Store at ambient temperature: Keep in