Product image of Montelukast Accord (Montelukast Sodium) supplied by GNH India

Montelukast Accord

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Accord (Montelukast Sodium)

Montelukast Sodium, the active ingredient in Montelukast Accord, is a leukotriene receptor antagonist presented as an oral dosage form for oral use. It treats asthma, allergic rhinitis and exercise‑induced bronchoconstriction in adults and children.

GNH India supplies Montelukast Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Ireland Limited

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Indications & Clinical Uses

Montelukast Accord, a leukotriene receptor antagonist, is used to manage conditions driven by cysteinyl leukotriene‑mediated inflammation.

  • Asthma: improves control of persistent asthma and reduces the frequency of exacerbations.
  • Allergic rhinitis: relieves nasal congestion, sneezing and itching associated with seasonal or perennial allergic rhinitis.
  • Exercise‑induced bronchoconstriction: prevents narrowing of the airways that occurs during or after physical activity.

How It Works

  • Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth muscle, inflammatory cells and vascular endothelium. By antagonizing this receptor, it inhibits leukotriene‑mediated bronchoconstriction, mucus secretion, vascular permeability and eosinophilic inflammation, thereby improving airway patency and reducing allergic inflammation.

Side Effects

Common Side Effects

  • Headache: mild to moderate headache reported in clinical use.
  • Abdominal pain: occasional stomach discomfort or cramping.
  • Nausea: transient feeling of queasiness.
  • Dizziness: light‑headed sensation, usually transient.

Serious or Rare Side Effects

  • Allergic reactions: rash, angioedema or anaphylaxis requiring immediate medical attention.
  • Neuropsychiatric events: depression, mood changes, suicidal thoughts or behavior.
  • Hepatic enzyme elevation: abnormal liver function tests observed rarely.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess asthma control: ensure patient is on appropriate inhaled therapy before adding montelukast.
  • Monitor neuropsychiatric symptoms: watch for mood changes, depression or suicidal ideation.
  • Use caution in hepatic impairment: evaluate liver function and adjust therapy if needed.
  • Avoid in known hypersensitivity: discontinue if allergic reaction to montelukast or excipients occurs.
  • Store at room temperature (below 25°C): keep in the original pack, protect from moisture.

Avoid Interactions

Montelukast may interact with several medicines; review patient medication lists carefully.

Major Interactions (Avoid)

  • Phenobarbital: induces metabolism and may lower montelukast plasma levels.
  • Rifampin: strong enzyme inducer that can reduce montelukast exposure.
  • Carbamazepine: may decrease montelukast concentrations through hepatic induction.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential alteration of INR; monitor coagulation parameters.
  • Theophylline: additive bronchodilator effect; observe clinical response.
  • CYP3A4 inhibitors (e.g., ketoconazole): may increase montelukast levels, requiring observation.

Frequently Asked Questions

Montelukast Accord is prescribed to manage persistent asthma, relieve symptoms of allergic rhinitis, and prevent exercise‑induced bronchoconstriction. It works by targeting leukotriene pathways that contribute to airway narrowing and inflammation, providing an oral option that complements inhaled therapies.

Montelukast blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth muscle and inflammatory cells. By preventing leukotrienes from binding, it reduces bronchoconstriction, mucus production, vascular leakage and eosinophilic inflammation, which together improve breathing and lessen allergic symptoms.

The specific dose of Montelukast Accord is determined by the prescribing healthcare professional based on the patient’s age, condition severity and concomitant therapies. Clinicians follow approved dosing guidelines, and patients should follow the exact regimen written on their prescription.

Safety data for Montelukast during pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against possible risks and discuss them with the patient. Women who are pregnant, planning pregnancy, or breastfeeding should consult their physician before starting therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or antihistamines for asthma and allergic rhinitis. While inhaled steroids directly reduce airway inflammation, montelukast provides convenient once‑daily dosing and is especially useful for patients with exercise‑induced symptoms or those who prefer oral therapy.

Montelukast Accord should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments.

Montelukast Accord is taken orally, usually once daily in the evening. It can be swallowed with water and may be taken with or without food, according to the prescribing clinician’s instructions.

Serious risks include neuropsychiatric events such as depression, mood changes or suicidal thoughts, as well as severe allergic reactions like rash, angioedema or anaphylaxis. Patients should seek immediate medical attention if they experience any of these symptoms.

Montelukast Accord should be avoided in individuals with known hypersensitivity to montelukast sodium or any of the tablet’s excipients. Caution is also advised for patients with severe hepatic impairment, and it should only be used under medical supervision in such cases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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