Product image of Montelukast Accord (Montelukast Sodium) supplied by GNH India

Montelukast Accord

Active Ingredient:
Montelukast Sodium
Origin:
EU

Montelukast Accord (Montelukast Sodium)

Montelukast, the active ingredient in Montelukast Accord, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is employed to treat asthma, allergic rhinitis, and to prevent exercise‑induced bronchoconstriction in adults and children. The medication works by blocking cysteinyl leukotriene receptors in the airways, reducing inflammation and narrowing of the bronchial tubes.

GNH India supplies Montelukast Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and health‑care institutions worldwide. The company provides reliable logistics and regulatory support to ensure timely delivery.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Montelukast, a leukotriene receptor antagonist, is used to manage respiratory conditions driven by leukotriene‑mediated inflammation.

  • Asthma: improves long‑term control and reduces frequency of asthma exacerbations in patients requiring maintenance therapy.
  • Allergic rhinitis: relieves nasal congestion, sneezing and itchy eyes associated with seasonal or perennial allergic rhinitis.
  • Exercise‑induced bronchoconstriction: prevents airway narrowing during or after physical activity, allowing better exercise tolerance.

How It Works

  • Montelukast selectively antagonizes the cysteinyl leukotriene receptor CysLT1 located on airway smooth muscle and inflammatory cells. By blocking this receptor, it inhibits leukotriene‑mediated bronchoconstriction, vascular permeability, and eosinophil recruitment, thereby reducing airway inflammation and hyperresponsiveness associated with asthma and allergic rhinitis.

Side Effects

Montelukast may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache
  • Abdominal pain
  • Cough
  • Nausea

Serious or Rare Side Effects

  • Angioedema or swelling of the face, lips or tongue
  • Mood changes, including depression or suicidal thoughts
  • Severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

When prescribing Montelukast, clinicians should consider several precautionary measures to ensure safe use.

  • Assess asthma control before initiation: confirm that patient’s disease is stable on current therapy.
  • Monitor for neuropsychiatric events: watch for mood swings, depression or suicidal ideation.
  • Use caution in hepatic impairment: dose adjustment may be required in patients with liver dysfunction.
  • Avoid use in patients with known hypersensitivity: discontinue if allergic reaction occurs.
  • Review concomitant medications for interactions: especially CYP inducers or inhibitors.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Montelukast can interact with other medicines, affecting its plasma levels or therapeutic response.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin): may markedly reduce montelukast exposure.
  • Concurrent use with phenobarbital: accelerates metabolism leading to loss of efficacy.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, fluconazole): may increase montelukast concentrations.
  • Oral contraceptives: monitor for potential reduced contraceptive effectiveness.
  • Warfarin: observe INR values as montelukast may alter anticoagulant response.

Frequently Asked Questions

Montelukast Accord is prescribed to manage chronic asthma, alleviate symptoms of allergic rhinitis, and prevent exercise‑induced bronchoconstriction. It works as part of a maintenance regimen to reduce airway inflammation and improve breathing stability in patients with these respiratory conditions.

Montelukast selectively blocks the cysteinyl leukotriene receptor CysLT1 on airway smooth‑muscle cells and inflammatory cells. By inhibiting leukotriene binding, it prevents bronchoconstriction, reduces vascular permeability, and limits eosinophil recruitment, thereby decreasing airway inflammation and hyper‑responsiveness.

The appropriate dose of Montelukast Accord is determined by the prescribing healthcare professional based on the patient’s age, condition, and clinical response. Standard dosing guidelines exist for different indications, but the exact regimen should be individualized by the prescriber.

The safety of Montelukast in pregnancy and lactation has not been definitively established, and it is classified as having an unknown pregnancy category. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the medication.

To place an order, submit an enquiry on the Montelukast Accord product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Montelukast belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting beta‑agonists for asthma control. While inhaled steroids target broader inflammatory pathways, Montelukast specifically blocks leukotriene‑mediated effects, which can be advantageous for patients who prefer oral therapy or have aspirin‑exacerbated respiratory disease.

Montelukast Accord tablets should be stored at room temperature, below 25 °C, in their original blister pack or container. Protect the product from moisture, excessive heat and direct sunlight to maintain stability throughout its shelf life.

Montelukast Accord is taken orally as a tablet, swallowed whole with water. It may be taken with or without food, according to the prescriber’s instructions. Consistency in the time of day helps maintain steady drug levels.

Serious adverse events include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, and neuropsychiatric effects like depression, mood swings or suicidal thoughts. Patients should seek immediate medical attention if they experience swelling of the face or lips, unusual skin eruptions, or significant changes in mood or behavior.

Montelukast Accord should be avoided in individuals with known hypersensitivity to montelukast or any component of the formulation. Caution is also advised for patients with severe hepatic impairment, and it is not recommended for use in children under the age approved for the specific indication without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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